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2582214
Cholera
Descripción
Overview of Cholera and treatment using ORT from AQA AS Biology Nelson Thornes book
Sin etiquetas
aslevel
biology
aqa
cholera
disease
vibrio cholerae
diarrhoea
oral rehydration therapy
ort
Mapa Mental por
charharrison
, actualizado hace más de 1 año
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charharrison
hace más de 9 años
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Resumen del Recurso
Cholera
Prokaryotic cells
'Before nucleus'
No nucleus or nucleolus
Only a diffuse area of nuclear material
Circular strands of DNA and a plasmid but no chromosomes
No membrane-bound organelles
Smaller 70S ribosomes
Cell wall made of peptidoglycan
Bacterial cell
Cell wall
Protects against mechanical damage
Excludes certain substances
Made of peptidoglycan
Capsule
Slime layers that protects bacterium
Sticks cells together
Cell-surface membrane
Differentially permeable membrane
Flagellum
Rigid, corkscrew shape
Movement
Circular DNA
Genetic information for replication
Plasmid
Genes to aid survival (antibacterial resistance)
Vibrio cholerae
Transmitted through water ingested and contaminated with faecal matter
Most killed in stomach acid
Produces a toxin
Causes loss of microvilli
Mechanism of infection
1. Bacterium enters the small intestine and flagellum propels itself into mucus
2. Produces a toxin made up of two parts
3. One part binds to specific glycoprotein receptors of epithelial cells
4. The other toxic part enters the cells and causes chloride channel ions to open
5. Chloride ions flow into lumen of the small intestine
6. This raises the cells water potential and lowers the lumen's water potential
7. Ions move into the epithelial cells from the surrounding tissues and blood due to conc. gradient and loss of chloride ions
8. Water moves by osmosis from the cells and other tissues into the lumen
Symptoms
Diarrhoea
Dehydration
Some show no symptoms
Treatment
Oral rehydration threapy
Makes use of alternative carrier proteins in epithelial cells
Stimulates sodium ion uptake
Drinking water is ineffective as intestine isn't absorbing water
Water
Rehydrate cells
Sodium
Make optimum use of sodium-glucose channel proteins
Glucose
Energy and sodium ion uptake
Potassium
Stimulate appetite
Other electrolytes
Prevent imblanace
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