Antiinfective Drugs

Descripción

(DHYG 325- Pharmacology) Mapa Mental sobre Antiinfective Drugs , creado por fandrickb2 el 05/12/2013.
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Mapa Mental por fandrickb2, actualizado hace más de 1 año
fandrickb2
Creado por fandrickb2 hace casi 11 años
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Resumen del Recurso

Antiinfective Drugs
  1. Bacteriocidal
    1. Drugs that interfere with the cell wall
      1. Penecillins, cephalosporins, bacitracin
        1. Penicillins
          1. Gram + cocci
            1. Penicillinase resistant: enzyme produced by staphylococci making it microbe resistant.
            2. Extended spectrum g+/-: e coli, H influenzae, proteus mirabilis
              1. ampicillin, amoxocillin: claculanic acid is penicillinase resistant.
            3. Cephalosporins: spectrum varies w each generation + to more -
              1. 10% cross hypersensitivity w penicillin
          2. Drugs that interfere with the cell membrane
            1. antifungals: nystatin, ketoconazole, clotrimazole
          3. Bacteriostatic
            1. drugs that interfere with protein synthesis:
              1. metronidazole, tetracyclines, clindamycin, erythromycin
                1. Tetracyclines: broad spectrum (gram +/-)
                  1. bind to calcium: bad for pregnat/breastfeeding women
                    1. ADR: GI upset, stomatitis, superinfection, photosensitivity, enamel hypoplasia,tooth staining
                    2. Macrolides: gram + microbes
                      1. used in ppl w penicillin allergies (clarithromycin & azithromycin common in dentistry)
                        1. ADR: GI upset , stomatitis, candidiasis
                          1. Interactions: eryth: bronchodialator (inc theophylline levels), inc. warfarin effect, dec. Birth control pill effect
                          2. Metronidazole: inhibits PRO synthesis (not normal)
                            1. perio anaerobic infections: NUG/NUP
                              1. avoid alcohol (food, drink, rinses)
                      2. Antifolates
                        1. drugs that interfere with nucleic acid synthesis
                          1. sulfa, quinalones (ciprofloxacin & norfloxacin), & antiTB drugs (rifampin & isoniazid)
                            1. Fluoroquinolones: affect bacterial DNA
                              1. avoid elecive dental Tx if TB+
                                1. Dr consult to confirm liver function
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