4250614
Signalling and
Receptor
- RECEPTORS
- What are they?
- Receptor are proteins found on the
plasma membrane or inside cells
- Receptor are proteins found on the
plasma membrane or inside cells
- How do they work?
- Positive Physiological Response = Agonist Ligand
Negative Physiological Response = Antagonist Ligand
- Positive Physiological Response = Agonist Ligand
Negative Physiological Response = Antagonist Ligand
- Types
- Enzyme- coupled Receptors
- Ligand attaches to receptor
- Two receptors join together (dimerization)
- Enzymatic reaction (induced or direct)
- Kinases
- Phoshorylates -OH on serine, threonine and
tyrsoine in proteins
- Phoshorylates -OH on serine, threonine and
tyrsoine in proteins
- Phoshphatases
- GTPase
- GEF
- GAP
- GEF
- RTK
- MAP Kinase
- Kinases
- Ligand attaches to receptor
- G-Protein coupled
- Channel
- Enzyme- coupled Receptors
- Inactivation of Receptors
- Engulfed, ligand leaves
receptor, ligand broken down,
receptor recycled
- Direct inactivation
e.g using
phosphotases
- Negative Feedback
- Engulfed, ligand leaves
receptor, ligand broken down,
receptor recycled
- What are they?
- MODES OF CELL SIGNALLING
- Paracrine
- A cell excretes ligand which effects neiighbouring
cells as it spreads out by diffusion
- A cell excretes ligand which effects neiighbouring
cells as it spreads out by diffusion
- Endocrine
- Ligand excerted into blood stream
- Ligand excerted into blood stream
- Synaptic
- Neurotransmitters between neurone
- Neurotransmitters between neurone
- Contact Dependant
- Paracrine
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