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Dopamine Pathways in the brain by
Tosin
- Mesolimbic
- Physiology: Projections from VTA (A10) to N. Ac (the Olf Bulb and Amgydala also)
- Motivation, Emotion, REWARD!
Nota:
- Regulates these behaviours
- Overactivity = Positive Symptoms of Szh
Nota:
- These include Delusions, Hallucinations and Thought Disorder and other Psychosis (reality testing is impaired) Furthermore = Catatonia (immobility/ non-purposeful movement)
- Motivation, Emotion, REWARD!
- D2 Antagonism Here = Alleviate Positive
symptoms in Szh
Nota:
- Underactivity of this results = Antipsychotic Drug MOA
- Physiology: Projections from VTA (A10) to N. Ac (the Olf Bulb and Amgydala also)
- Mesocortical
- Physiology: Projections from VTA (A10) to
Prefrontal Cortex (PFC)
- Dorsal Lateral PFC = Cognitive Functions
- Cognitive Deficits in Szh
- Cognitive Deficits in Szh
- Ventral Lateral PFC = Emotions and Affect
- Overactivity = Negative Symptoms of Szh
- Overactivity = Negative Symptoms of Szh
- Dorsal Lateral PFC = Cognitive Functions
- D2 Antagonism here = Alleviate Szh Symptoms
- Physiology: Projections from VTA (A10) to
Prefrontal Cortex (PFC)
- Nigrostriatal Pathway
- Physiology = Projections from Substantia Nigra (A9) to Striatum (caudaute nuclues and putamen)
- Controls Movement indirectly - Overactivity = Tardive Dyskinesia & Underactivity = Parkinsonism
Nota:
- See Basal Ganglia Pathways! Involved in preventing non-purposeful movement
- Parkinsonism = Movement disorder & clinical syndrome caused by lesions/damage to Basal ganglis'a Substantia Nigra
- Controls Movement indirectly - Overactivity = Tardive Dyskinesia & Underactivity = Parkinsonism
- D2 Block = Antipsychotic use side affects
Nota:
- In particular the Extrapyramidal side effects = movement disorders
- These disorders involve involuntary movements
- Physiology = Projections from Substantia Nigra (A9) to Striatum (caudaute nuclues and putamen)
- Tuberoinfundibular
- Physiology = Projections from Hypothalamus (arcuate and periventricular nuclei) to
infundibular region in medial eminence
Nota:
- From one part of the hypothalamus to the other
- Portal circulation between Medial eminence and Anterior pituitary = Dopamine released here
- Dopamine inhibits Prolactin release
- Hyperactivity = Too little Prolactin
- Underactivity = Too much Prolactin
Nota:
- So D2 Blockade = Hyperprolactineamia
- This is another side effect of Antipsychotic Drugs
- Physiology = Projections from Hypothalamus (arcuate and periventricular nuclei) to
infundibular region in medial eminence
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