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C3

Descripción

Complement pathways
Amaal Salhieh
Mapa Mental por Amaal Salhieh, actualizado hace más de 1 año
Amaal Salhieh
Creado por Amaal Salhieh hace casi 9 años
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Resumen del Recurso

C3
  1. iC3
    1. D Cleaves B into Ba and Bb
      1. Ba is released
        1. Bb + iC3 = iC3b
          1. iC3b
            1. cleaves C3 into C3a and C3b
              1. C3b attaches to pathogen
                1. D cleaves B into Ba and Bb
                  1. C3b + Bb = C3bBb
                    1. alternative C3 convertase
                      1. alternative C5 convertase
                        1. C3b2Bb
                          1. Cleaves C5 into C5a and C5b
                            1. C5b initiates membrane-attack complex
                              1. C6, C7, C8 bind
                                1. C9 polymerizes
                              2. C5a
                                1. Analphylatoxins
                            2. + C3b
                          2. Ba is released
                          3. B
                          4. C3a
                            2. classical C3 convertase
                              1. C4bC2a
                                1. C2a
                                  1. C2
                                      1. C2b
                                    2. C4b
                                      1. C4
                                        1. cleaves
                                          1. MASP2
                                            1. Lectin Pathway
                                            2. C1s
                                              1. CRP
                                                1. binds to C1q
                                                  1. C1r cuts itself
                                                    1. C1r cuts other C1r
                                                      1. <-- C1r cuts both C1s
                                                        1. C1s
                                                    2. Classical Pathway
                                                2. C4a
                                                  1. Anaphylatoxins
                                      2. soluble C3 convertase
                                    3. B
                                    4. Hydrolysis
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