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5214016
Innate Immunity
Descripción
Innate Immunity
Sin etiquetas
microbiology
immunity
immune
microbiology
undergraduate
Mapa Mental por
Mohd Amirul Faiz Zulkifli
, actualizado hace más de 1 año
Más
Menos
Creado por
Mohd Amirul Faiz Zulkifli
hace más de 8 años
300
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Resumen del Recurso
Innate Immunity
First Line of Defense
Physical barrier
Skin
Skin form waterproof mechanical barrier
Prevent entry of microbes
Mucus lining
Trap dirt and microbes
Chemical barrier
Saliva
Contain enzyme that breaks down the cell wall of bacteria
Stomach acid
Has low pH acid that kills bacteria and parasites
Tears
Contain enzyme that breaks down the cell wall of bacteria
Second Line of Defense
Group of cells, tissues and organs that work together
To protect the body
It create hostile environment for the invaders
It has four components
Fever
The body temperature increase to 37 C and above
It initiated by pyrogens
It change the settings of hypothalamus
Reduced iron availability
Iron-required pathogens cannot get the iron needed
Inhibition of microbial multiplication
Creating sub optimal temperature
Increase metabolic rate
Stimulates immune reactions
Inflammation
Symptoms
Redness
Heat
Pain
Oedema
Stages
Tissue injury
Dilation and increased leakiness
Phagocytes consume bacteria
Release of cytokines
Causing vasodilation
Phagocytosis
Contain phagocytes
They possess lysosome containing substances
Stages
Attachment
Ingestion
Killing
Degradation
Antimicrobial proteins
Four main types
The complement system
Work in cascade reactions
Three pathways
Classical
Lectin
Alternative
Interferons
Involve cytokines to against virus
Iron-binding protein
Limit the growth of pathogens
Examples
Hemoglobin
Lactoferrin
Transferrin
Antimicrobial peptides
Kill bacteria by inserting them into the membrane
It is non-specific
Immune components are preformed
Response magnitude is similar during the first and subsequent encounters
No memory is stored
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