cAMP Pathway

1. alpha GTP
   1. alpha GDP
   2. Gi (inhibitor)
      1. inhibit Adenyl Cyclase
         1. ATP to cAMP decrease
   3. Gs ( stimulate)
      1. ATP to cAMP increase

         Nota:

         • second messenger
         1. Protein Kinase A increase
            1. Enzymes Phosphorylated
               1. turn on
               2. turn of
            2. CREB phosphorylated
               1. Go inside to nucleus
                  1. bind to CRE

                     Nota:

                     • cAMP Response Element
                     1. Gene Experesion
            3. 5
         2. Stimulate Adenyl Cyclase
            1. 3
         3. 4
2. beta, gama

Nota:

• Inactive G protein