Glycolisis

Nota:

• commited step 1st rxn.

1. Prep. gluc.+2ATP-> 2GAG
   1. Phosphorilation
      1. Gluc.+HK+ATP+Mg--->G6P
         1. HK-low km G6P-inhib
      2. Isomerization
         1. G6P+PGI-->F6P
         2. 2d Phosphorilation
            1. F6P+PFK+ATP+Mg--->FPB
               1. Limiting step
               2. Irreversible
            2. Cleavage
               1. FBP+Aldolase--->DHAP+GAP
                  1. DHAP-->int.Enediol-->GAP
                     1. ketose to aldose
               2. Prod. energy 2GAP-->2pyruvates+4ATP+2NADH
                  1. Oxidation
                     1. GAP+GAPDH-->1,3-BPG
                        1. NAD+Pi-->NADH+H
                     2. ATP Formation
                        1. 1,3-BPG+PBG
      3. Commited step
         1. Irreversible