Lecture 08 Anterolateral Pathway for Temperature, Pain and Itch

Pathway for temperature, pain and itch located in the ______

T/F: A-delta fibers are not myelinated.

Which pain fiber is unmyelinated?

Which sensation does C fibers transmit?

What are the names of the free nerve endings related to temperature, itch and pain?

What are the sub-categories of nociceptors?

What are the channels that sense temperature change signals?

Which of the following is mostly for cold, which is mostly for warmth?
TRPA1, TRPM8, TRPV1, TRPV2

TRPA1 also responds to ______.
TRPM8 also responds to _____.
TRPV1 responds to ______.

TRPM8 generates pin sensation due to ____.
TRPVs usually respond to pain from ______.
TREK -1 is both responsive to ______ and _____.
Anything with ASIC is likely pain due to ________.
MDEG and TRASIC are also responsive to _______.

A polymodal nociceptor, TRPV1 is responsive to _____, _____, ____, and ______.

First pain, or sharp pain, is signals from _______ fibers.

Second pain, or dull pain, is signals from _________.

T/F: pain is either sharp or dull, and cannot be both.

The second order neurons travel in the _______ of the spinal cord and terminates in _______.

Our conscious perception of the pain synapses in the ____ to proceed to the ______. This is called the _____ pathway.

Aside from synapsing in the thalamus, the 2nd order neurons may also synapse in the ______ or the _______, called the _________ and ________ respectively.

in the midbrain, the synapsed axons goes to the ______ while in the pons, they travel to the ______.

The first order neurons synapse with the second order neurons in the _____ for the anterolateral pathway. It then decussates in the _________ before entering the thalamus.

Other than the VPL, where else might the anterolateral pathway synapse?

Why does a common body region span 1-4 spinal segments?

After entry to the dorsal horn, the 1st order neurons synapse with interneurons (Second order neurons) in _______, __or ___.

Rexed I is also called the ______

Rexed II is also called the _____

Rexed V is also called the _____.

Some second order neurons in Rexed ___ or __ may decussate in the _____________ and enter the _______ system.

T/F: Rexed I, II and V all participate in output.

Substantia gelatinosa also receives ____ pain.

On the cross section, the substantia gelatinosa looks like _____.

Conscious perception of visceral pain travels in the ________.

Identify the location of ALS in the cross-sections.

3rd order thalamocortical neurons in ALS go to different locations on the cortex. VPL goes to _______, VMp (Ventral posteromedial) goes to ______, while MD (medial dorsal) goes to _______.

Locate the reticular formation on the cross-sections.

Where does the spinoreticular tract synapse?

Where does the spinomesencephalic tract synapse?

PAG sends out projection to raphe nuclei (ipsilaterally / contralaterally/ bilaterally)

Where does raphe nuclei synapse back to? What does the loop modify?

The PAG is driven by ________ pathway.

Outline the visceral pain pathway.

Brown-Sequard Syndrome is a ________.