Pathology of Lymphoma

B cell development

T cell development

What is lymphoma?

B cell neoplasms (3)

T cell neoplasms

How can immunohistochemistry be used in investigating possible leukaemia/lymphoma?

What is FISH?
used to detect what?

General categories of lymphoma

Low grade lymphoma
- size
- proliferation and apoptosis
- clinical presentation
- prognosis

High grade lymphoma
- size and appearance
- proliferation and apoptosis
- spread
- prognosis

low grade vs high grade lymphoma using immunohistochemistry

Ann Arbor Staging

Follicular lymphoma
- what
- who
- presentation
- prognosis

Morphology of follicular lymphoma

Genetic abnormality in follicular lymphoma

how detected?

Treatment of follicular lymphoma

Burkitt lymphoma
- what
- 3 variants

How does Burkitt lymphoma present?

Treatment of Burkitt lymphoma

prognosis?

Microscopy of Burkitt lymphoma

Genetic abnormality in Burkitt Lymphoma

Treatment and prognosis of Burkitt Lymphoma

Diffuse Large B-Cell Lymphoma
- clinical course
- % lymphoma
- who
- clinical presentation

Microscopy of DLBCL

Genetic abnormality in DLBCL

Treatment and prognosis of lymphoma
germinal centre B cell-like vs activated B-cell-like?

Hodgkin lymphoma
- what
- characterised by

Classic Hodgkin lymphoma
- % lymphomas
- age
- presentation
- unusual symptoms

Reed-Sternberg cells

Morphological subtypes of HL

REED Sternberg immunohistochemistry

Prognosis of HL

Where are Auer rods seen?