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Biological Models:
(A) ( Genetic, Biological, Cognitive ) Evidence:
-depression & bipolar run in ( families, blood, DNA )
-family studies: the closer genetic relationship
*Genetic contribution is stronger for bipolar vs. depressive
(B) Biochemical Factors & Brain Abnormalities:
-cause or effect?
Catechloamine Ho: non-functioning NE or DA
-depression- receptors too few or insensitive
support= anti-depressants boost NE work
Prefrontal cortex: lower metabolic activity--> lower motivation
*limbic system abnormalities:
-( hippocampus, Amygdala, Pre-frontal Cortex ): lower metabolic activity: higher levels of cortisol
-( amygdala, Hippocampus, frontal lobe ): enlarged