Michael Jardine
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PHSI3012 09-2 Vascular Inflammation (T2L8)

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Michael Jardine
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PHSI3012 09-2 Vascular Inflammation

Pregunta 1 de 8

1

The following are key inflammatory proteins involved in the initiation of atherosclerosis.
1) Selectins;
2) Chemokines (and Chemokine receptors);
3) Integrins;
4) CAMs.
What are CAMs?

Selecciona una de las siguientes respuestas posibles:

  • Cell Adhesion Molecules

  • Chemokine Adhesion Molecules

  • Cell Adherance Molecules

  • Chemokine Adherance Molecules

Explicación

Pregunta 2 de 8

3

Selectins are a family of 3 C-type lectins expressed exclusively by bone marrow-derived cells and endothelial cells. They include which of the following types?

Selecciona una o más de las siguientes respuestas posibles:

  • L (Leukocyte) – selectin

  • E (Endothelial) – selectin

  • P (Platelet + Endothelial) – selectin

  • E (Epithelial) – selectin

  • P (Platelet + Epithelial) – selectin

  • M (Mesenchymal) – selectin

  • M (Myokine) – selectin

Explicación

Pregunta 3 de 8

3

Which of the following are key SELECTIN ligands?

Selecciona una o más de las siguientes respuestas posibles:

  • PSGL1

  • ESL-1

  • CD34

  • CD44

  • CD46

  • CD36

  • VCAM-1

  • ICAM-1

  • TNF

  • CSF

Explicación

Pregunta 4 de 8

2

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Integrins are membrane-bound proteins that are key inflammatory proteins. They’re heterodimers with α and β subunits. They include αLβ2, VLA-1, α4β1, LFA-1. Three integrin conformations have been described (bent form with closed headpiece; extended form with closed headpiece; extended form with open headpiece). Of these, the ( Bent with closed headpiece, Extended with closed headpiece, Extended with open headpiece ) is the only one with HIGH affinity for ligand.
They can be activated by either chemokine engagement or selectin engagement. One results in rolling SLOWING, the other in it STOPPING. Which stops it? ( Chemokine engagement, Selectin engagement ).

Explicación

Pregunta 5 de 8

3

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CAMs include Intercellular (ICAM) and Vascular (VCAM). (and others)
( VCAM-1, ICAM-1 ) is predominantly expressed on endothelial cells, but is also present on SMCs. Binds to VLA1 (Very Late Antigen-1) and α4β1 integrins.
( ICAM-1, VCAM-1 ) is expressed on endothelial cells but also on leukocytes including neutrophils and monocytes.
Both are produced by inflammation but ( ICAM-1, VCAM-1 ) is more constitutively expressed

Explicación

Pregunta 6 de 8

2

Three forms of cell death are described. Which is which?
= “dead body”;
= “eating of self”;
= “falling off”.

Arrastra y suelta para completar el texto.

    Necroptosis
    Autophagy
    Apoptosis

Explicación

Pregunta 7 de 8

1

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TRAIL = Tumour necrosis-factor Related Apoptosis-Inducing Ligand.
It’s a member of the ( TNF, NFKB, ICAM-1, VCAM-1, PSGL1, ESL-1, ELS-1 ) ligand family.
Causes apoptosis of cancer/tumour cells; in clinical trials for cancer therapy. Emergence of non-apoptotic functions in normal cell.

Explicación

Pregunta 8 de 8

1

Selecciona la opción correcta del menú desplegable para completar el texto.

Trail-/- (complete knockout) mice develop PVD and have ( Impaired, Restored ) vascularity in reponse to ischaemia.

Explicación

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