Tissue remodelling regeneration renewal proliferation( remodelling, regeneration, renewal, proliferation ): the ECM of granulation epithelial vascular( granulation, epithelial, vascular ) tissue must be degraded to remodel redesign( remodel, redesign ) tissue in healing. Matrix metalloproteinases (MMPs) are enzymes cytokines growth factors caspases( enzymes, cytokines, growth factors, caspases ) that each break down one component of this ECM. They mediate long- term scar maturation and degradation, which is why they can look better over time. The action of MMPs is regulated by TIMPs SIMPs PIMPs DIMPs( TIMPs, SIMPs, PIMPs, DIMPs ).

Fibrotic tissue is weaker stronger( weaker, stronger ) and less more( less, more ) elastic than healthy tissue.

Fibroblasts are connective tissue stem cells. Growth factors Cytokines Platelets Histamines( Growth factors, Cytokines, Platelets, Histamines ) cause them to migrate and proliferate differentiate hallucinate debate situate( proliferate, differentiate, hallucinate, debate, situate ). They secrete ECM components, collagen fibrinogen platelets lipids( collagen, fibrinogen, platelets, lipids ) and elastin.