A mutation removes a single base pair within the coding sequence of a gene and inactivates the protein encoded by the gene. Such a mutation is
A silent mutation
A missense mutation
A nonsense mutation
A frameshift mutation
Both b and c
Some point mutations lead to an mRNA that produces a shorter polypeptide. This type of mutation is known as a _________ mutation.
neutral
silent
missense
nonsense
chromosomal
In which location is a mutation least likely to affect gene function?
Promoter
Coding Region
Splice Junction
Intergenic Region
Regulatory site
Mutagens can cause mutations by
chemically altering DNA nucleotides
disrupting DNA replication
altering the genetic code of an organism
all of the above
a and b only
The mutagenic effect of UV light is
the alteration of cytosine bases and adenine bases
the formation of adenine dimers that interfere with genetic expression
the breaking of the sugar-phosphate backbone of the DNA molecule
the formation of thymine dimers that disrupt DNA replication
the deletion of thymine bases along the DNA molecule
The Ames test
provides a way to determine if any type of cell has experienced a mutation
provides a way to determine if an agent is a mutagen
allows researchers to experimentally disrupt gene activity by causing a mutation in a specific gene
provides a way to repair mutation in bacterial cells
does all the above
Xeroderma pigmentosum
is a genetic disorder that results in uncontrolled cell growth
is a genetic disorder in which the NER System is not fully functional
is a genetic disorder that results in the loss of pigment in certain patches of skin
results from the lack of DNA polymerase proofreading
Both b and d are true of this disorder.
If a mutation eliminated the function of UvrC, which aspect of nucleotide excision repair would not work?
Sensing a damaged DNA site
Endonuclease cleavage of the damaged strand
removal of the damaged strand
synthesis of a new strand, using the undamaged strand as a template
none of the above
Cancer cells are said to be metastatic when they
begin to divide uncontrollably
invade healthy tissue
migrate to other parts of the body
cause mutations in other healthy cells
do all of the above
Oncogenes can be produced by
missense mutations
gene amplification
chromosomal translocation
retroviral insertion
