General Pathoanatomy Final MCQs (401-519)- 3rd Year- PMU

What change of the lung is described? — H-E staining: The alveoli are filled with siderophages. They accumulate golden-brown pigment as a result of phagocytosis of the hemolized erytrocytes due to intra-alveolar per-diapedesin hemorrhages. Intraalveolar septa are thickened because of the development of connective tissue.

The following microscopic description indicates:
"Yellow-brown-green pigment is accumulated as tiny granules in the cytoplasm of the hepatocytes, in the lumens of the biliary capillaries as bile thrombi and in the lumens of bileducts as cylinders.

The following microscopic description indicates:
H-E staining: The epithelial cells of the renal tubules accumulate yellow browm-green pigment as tiny granules in their cytoplasm. The same pigment is accumulated as cylinders in the lumens of the straight and collective renal tubules

The following microscopic description indicates:
H-E staining: The lesion consists of nests of normal melanocytes that accumulate different quantity of brown-black pigment. These cells can be found in papillary or reticular derma of the skin.

The following gross description of the lungs is typical for:
"Brick-red to brown colour of the lungs, firm consistency, decreased elasticity"

The following clinical features: left-sided heart failure, dyspnoe (shortness of breath), frequent cough with rusty colour expectoration, can be seen in:

Which heart disease can be described with the following microscopic picture'. The cuspid valve when stained with H-E shows loose area — clear and unstained spaces between fibrous structures representing interstitional mucoid
Fibroblasts are seen around this clear zone and in the periphery of the cuspid valve (sign of fibrosis). The valve contains many newly formed capillaries (the is called vascularization).

Which answer is correct for the following microscopic description: I-I-E staining: The liver columns are atrophic, the sinusoids look dilated. The hepatocytes are smaller in size and contain brown-golden pigment granules with perinuclear localization.

"The following description of the liver is indicative for:
The liver is increased in size, with firm texture, red-purple color, congested vessels, microscopically the sinusoids are dilated and filled with erythrocytes.

The following description of the liver is indicative for:
The liver is increased in size, with motley cut surface showing red areas surrounded by yellow halo:

The following microscopic description is indicative for:
H-E staining: Sinusoids are dilated and filled with blood. "Bloody lakes"are seen in the centro-lobular areas among the necrotic hepatocytes. The hepatocytes around them are with lipid degeneration and look like "signet-ring" cells. In the intermediate lobular areas the hepatocytes are atrophic.

The following microscopic description is indicative for:
H-E staining: Alveolar spaces are filled with precipitaded homogenous pink fluid. Alveolar septi and capillaries are dilated and filled with erythrocytes. Airy bubbles can be found in the alveolar cavities and in the lumens of bronchi.

Indicate the cause of death according to the described test.
"After Y-shaped opening of the pericardium, the pulmonary artery is cut on 2cm after its beginning. Tweezers are inserted in the vessel and its content is taken out, which looks dry and crumblie".

Indicate the cause of death according to the described test:
"After Y-shaped opeing, the pericardial sac is filled with water. After puncture of the right heart ventricle with a sharp knife are seen air bubbles".

The following microscopic description is indicative for:
H-E staining. Thrombus formation with layered structure, occluding completely or partially the lumen of the blood vessel. In the area of disturbed endothelial layer is seen alternation of pink stripes and bands (aggregated thrombocytes and fibrin fibres) and orange accumulations (erythrocytes).

The following microscopic description of the kidney is indicative for:
H-E staining: On low magnification is seen pinkish area with no nuclei or picnotic nuclei and the cytoplasms of the necrotic cells is granular and eosinophillic. Kidney structures look like shadows. This pinkish area is surrounded by blue rim, of inflammatory cells (lymphocytes and leucocyts) and thin band of erythrocytes (the so called hyperemic-hemorrhagic area).

The following microscopic description of the lung indicates for:
On H-E staining: Necropsy material taken 24 hours after death. The alveoli are filled with agglutinated and hemolized erythrocytes, the alveolar walls are necrotic. The preserved alveoli are filled with edematous fluid and hemosiderophages. The latest changes are a sign for chronic venous congestion.

The following microscopic description of the lung is indicative for:
The specimen is prepared by frozen section of unfixed tissue. Sudan Ill staining shows round, oval, elongated or branched, orange stained drops in the capillaries, with complete occlusion of their lumen.

What is the organ diagnosis if during autopsy are seen the following changes: Complicated atherosclerotic plaques of the aorta and renal arteries with ulceration and thrombosis, small in size right kidney showing depressed area in its middle part, which is 3x4cm in size, with pale color, firm texture and triangular shape.

The following microscopic description of the heart is indicative for: H-E staining: Among the myocardium are found cavities filled with purulent exudate. In the centre of some of them are seen groups of microorganisms, stained in dark blue. The adjacent cardiomyocytes are with dystrophic changes, multitude neutrophiles are seen in the interstitium.

What is the described disease in the liver?
H-E staining "Description of the wall of a cyst. Pink slender membrane is pathognomonic for the disease. It represents tick, multilayered acellular band which looks like "cigarette smoke". There is a fibrous capsule between the membrane and the normal liver tissue, compoused of collagen connective tissue. Single bile ducts and chronic inflammatory cells are included among the collagen fibres."

Suggest the correct answer according to the following microscopic description. H-E staining: The tumor is composed of branches and nests of basal type cells — spindle, with scanty cytoplasm and moderate atypia of nuclei. Mitoses are rarely seen. In the solid nests tumor cells have palisade peripheral arrangement The stromal reaction is presented by lymphocytes and plasma cells. The tumor nests infiltrate the deep dermal layers.

Indicate the correct answer for the following description: "Tumor-like process located on the gingiva. Histologically, under the stratified squamous gingival epithelium are found fibroblast-like cells and giant cells looking like osteoclasts, located in optically empty spaces. Light stripe of connective tissue separates the epithelium and the tumor-like process

Indicate the diagnosis according to the following microscopic description: H-E staining: The thyroid gland is lavishly infiltrated by the lymphocytes and plasma cells. Plenty of lymph follicles are also formed, they are with the wide light centres. The lymphoid infiltration disrupts the lymph follicles; in the preserved ones the colloid is scanty or missing. High cubic eosinophilic cells of Hurtle type can be seen.

Suggest the diagnosis according to the following microscopic description: H-E staining: Capsulated tumor with uneven, lobular structure. Different lobules are made up of cells containing optically empty vacuoles in their cytoplasm They push the cells' nuclei to the periphery under the cytoplasmic membrane.

Suggest the correct diagnosis according to the following microscopic description. H-E staining: Unencapsulated intradermal tumor which is poorly distinguished from the adjacent tissue and covered by the atrophic epidermis. The tumor is composed of the capillary vessels with erythrocytes in their lumena.

Suggest the diagnosis according to the following microscopic description. H-E stining: Unencapsulated liver tumor which is well distinguished from the adjacent tissues. It is composed of the large vascular spaces resembling similar vascular structures in the penis. Erythrocytes and hemolyzed blood are seen in the lumina of these large vessels. The walls of these structures represent fibrous septi covered with one or two lines of endothelial cells.

Suggest the diagnosis according to the jV)llowing microscopic description: Il-E staining: Unencapsulated uterine tumor which is composed of the spindle cells arranged in bundles. These bundles cross in different directions, Slight tissue atypia is seen, presented by chaotic bundles of spindle cells

Suggest the diagnosis according to the microscopic description. I-I-E staining: The tumor is composed of highly differentiated tissue elements from the three germinal cell layers -- mesodermal layer (connective tissue, collagen fibres, fatty tissue, cartilage and others), endodermal layer (glands) and ectodermal layer (skin, columnar epithelium, stratified squamous epithelium, brain substance). They create a variety of the morphological picture. There isn't any sign of cell atypia. Cystic changes are often seen.

A resident in surgery is looking for a consultation with regard to a breast nodule in a young woman: can a morphological examination be done prior to surgery? How the specimen should be taken and in what fixative? Which are the other options for a routine examination? What addition morphological methods can be involved?

The autopsy of a 65- year old patient, alcohol addicted with diabetes, emphysema and pneumonia revealed gross changes in the liver. It's enlarged and heavy (21 10g) with smooth surface and soft consistency. The cut surface is yellowbrown and the lobular structure is unclear. What is the diagnosis?

The autopsy of a patient with pernicious anemia showed dilated right heart chamber. The myocardium is loose and pale. As a result of the hypoxia, the major changes are seen under the endocardium, mainly in the area of papillary muscles. What changes do you expect to see?

52-year old woman with medical history of tonsillitis, developed heart valve defect. She complained of cough, sometimes with rusty expectoration and difficulties in breathing when she is lying in bed. Auscultation revealed small moist noises in both lung bases. What is the cause for all these complains and clinical findings?

Body of a man with total cachexia is sent for an autopsy. The skin is darkbronze. The two suprarenal glands are entirely ruined by tuberculosis. Which is the disease?

Nodule measuring 2cm from the parotid gland of a 32 year old male patient was sent for the histological examination. Histological result showed jelly-like and at some areas chondroid substance which surrounds glandular structures and strands of flat cylindrical and spindle cells. Suggest the diagnosis.

Autopsy of a young man died 2 days after car accident reveals fracture of the femur and massive crush of the soft tissues. Lungs are normal in shape and size but with expressive hyperemia. The cut surface is shiny with minute droplets of the size of the head of a pin. Indicate the cause of death:

Autopsy of a patient with pernicious anemia shows dilated right ventricle with anemic infarction. On papillary muscles are detected yellowish stripes. What pathological finding is seen in this case?

A tumor from the left forearm in a 39-year old woman was resected. Grossly it is well circumscribed, with a diameter of 3 cm. On histology: tumor cells are spindleshaped, grouped in bundles, nuclei form palisade structures. Set the diagnosis:

An autopsy of a 60-years all man revealed a thickened and soft wall of the stomach with indistinct layers. Cut surface showed presence of the dirty grayish -green pus-like material. What disease is this:

At an autopsy in the temporal lobe of the brain a cyst with a diameter of 2 cm, with smooth walls and clear pale yellow liquid was found .What can it be :

A man of 68 years is complaining of severe pain in the muscles of the legs occurring when walking fast, which disappears after a short rest. Indicate the correct diagnosis:

A week after surgery for inguinal hernia at the site of operation appears a nodule. Microscopically there are macrophages, lymphocytes and lots of capillaries with scattered neutrophils. What is a diagnosed?

Left hemisphere of brain demonstrates a well circumscribed tumor with a diameter of 3cm, greyish- brown color and a thick consistency, attached to the dura mater. The underlying brain tissue shows a compression pit. Point the most likely macroscopic diagnosis:

On the plantar surface of a 35 year old woman there is a bluish-black tumor with lobulated uneven surface covered with bloody crusts. Histology shows epithelioid cells with different shapes and sizes with pigment granules in the cytoplasm. Infiltrative gro•vvth in respect to dermis and epidermis is present. Give a diagnosis:

At an autopsy in the upper area of the right lung are detected changes including two foci with stone-hard density. The cut-surface is whitish and is grinding like sand. How to explain the presence of these calcium salts?

68 year-old man complains of a face ulcer with thick edges and black base covered with brownish crusts. Histologically nests of round cells that form peripheral palisade structures are seen. Which is the correct diagnosis?

A man of 62, smoker with obesity, treated in a dermatological clinic due to skin problems, dies suddenly after a severe chest pain . Clinicians set as the final diagnosis the skin disease for which he has been admitted to the hospital. At the autopsy a 3.5 cm clay-like area with irregular shape in the anterior wall of the left ventricle was seen. The descending left coronary artery was almost entirely occluded by atherosclerosis. What is the correct diagnosis?

The autopsy of a 43 years old man reveals brain meninges covered by the thick yellowish exudate. Meningeal vessels are hyperemic, brain tissue is edematous. What is your diagnosis?

A 35 year old man felt his right parotid gland enlarged, with a nodule 2 cm in diameter, well demarcated and dense. Histology shows jelly-like structures and immature cartilage and between them glandular structures and strands of cubic. cylindrical cells and ducts. Specify the diagnosis:

During the autopsy in the temporal lobe of the brain is found a cyst 2cm in diameter, with smooth walls filled with a clear pale yellow liquid. Indicate what it is:

At autopsy, in the abdominal cavity and on appendices epiploice, many "chalky" white spots are clearly seen. The finding is the same in the pancreas. Point the diagnosis:

The autopsy of a young man died several hours after a car accident shows fracture of his left femur with massive smash of the soft tissues. The lungs are normal in shape and size, but intensively congested. Their cut surface is shiny and small droplets the size of a 'pin head' appear on it. Specify the cause of death:

69 year old male, who has suffered from varicose veins of the legs for 20 years, is admitted for surgical treatment. 15 days after surgery, when he suddenly rose up from bed, he felt sick, complained of severe shortness of breath, lost consciousness and died within a few minutes. Indicate the most likely cause of death:

28 year old woman a year ago felt a 'knot' in the breast 2 centimeters in diameter, well demarcated, painless, mobile, thick. Histology shows concentric connective tissue around the ducts of the breast without compressing and distortion of the ducts. Specify the exact histologic diagnosis:

Bilateral on the skin of the eyelids are seen bulging above the level of the skin nodules yellow color with the size of rice grains. What is it?

The autopsy of a deceased patient shows swollen and very soft meninges of the temporal area with greyish-green color. Microscopic examination reveals that the meninges are rich of leukocytes. What illness is concerned:

The autopsy of an old man who died suddenly found complicated atherosclerotic plaques in the aorta, coronary and cerebral arteries. The heart is enlarged with dilated heart chambers. The right atrium shows brittle grey-brown material with uneven surface, close to the endocardium. The main trunk and two main branches of the pulmonary artery show 'saddle' grey-brown brittle material. Identify the immediate cause of death:

39 year old female underwent surgery to remove a tumor from her left forearm.
The tumor is 3cm in diameter, well demarcated and dense. Histology shows fusiform (spindle) cells which are grouped in bundles, with nuclei arranged in palisades ('fence wall' pattern). Set the diagnosis:

39-year-old female has surgically removed tumor from her left forearm measuring 3 cm in diameter, well demarcated and dense. Histology shows fusiform (spindle) cells grouped in bundles, with palisading ('fence' type pattern) nuclei. Specify the diagnosis:

At autopsy the stomach is with a large tumor with gelatinous appearance. Microscopically, the tumor cells show 'signet ring'-shaped appearance, in whose cytoplasm PAS reaction is positive. What type of degeneration is the pathological process associated the gelatinous appearance of tumor?

At autopsy in the frontal lobe of the brain is found well visible and demarcated area with 3 cm in diameter, with gray-green color, well circumscribed from the surrounding tissue, filled with decaying substance. What illness is described?

At autopsy, in the abdominal cavity and on appendices epiploice, many "chalky" white spots are clearly seen. The finding is the same in the pancreas. Point the diagnosis: