Resting membrane potential:
• All gated Na+ and K+ channels are closed.
• K+ leak channels (not visible on this image) are open which allow movement of K+ to the outside of the cell. This creates a negative intracellular charge = RMP.
• Na+/K+ pump also creates the RMP
❌
• Na+ gated channels open and Na+ moves into the cell and inside of the cell becomes more positive.
• K+ gated channels are closed.
• Membrane potential becomes more positive.
❌
• Na+ gated channels close.
• K+ gated channels open and K+ moves out of the cell and the intracellular side becomes more negative.
• Membrane potential becomes more negative.
❌
• Na+ gated channels close.
• K+ gated channels close as well but they close slowly so K+ continues to leave the cell and this produces the afterpotential.
• Membrane potential becomes very negative
❌
• Na+ gated channels are closed.
• K+ gated channels are closed.
• Resting membrane potential is re-established by Na+/K+ pump (an active process as it is against their concentration gradients) which redistribute ions as all Na+ and K+ gated channels are closed.
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