AP - Healing and repair

Resolution only occurs if tissue sustained ❌ damage - inflammatory reactions ❌ -> tissue is ❌ to former function and structure

Regeneration are usually in tissues where cells have ❌ ability. ❌ cells are ones that continue to ❌ in order to ❌ lost cells, whilst ❌ cells cease to multiply when growth of mature organ is reached.

Organisation is where damage is ❌ and ❌ is great. Inflammatory response ❌, ❌ is so great, ❌ forms and matures to form a ❌. Especially in tissues composed of permanent cells with no ❌ such as ❌.

There are 2 ways a skin wound will heal - ❌: Clean, precise ❌ and also the Second intension: There is ❌

Healing by first intension - There is ❌, and edges of wound are held ❌ by sutures or butterfly tape.

In healing by second intension, the ❌ gapes and there is ❌ of tissue due to infection. First stage is that there's an ❌ and excised wound, ❌ into wound and there are blood clots. Next stage is the ❌ of new epithelium in from sides and through the clot, and eventually meets in centre. ❌ tissue grows in from adjacent CT and base of wound. ❌ and endothelium

Last stage of second intension healing includes wound ❌, action of transformed ❌, they contrast and ❌ is laid down. This in turn ❌ wound size. There is also a ❌ in vascularity and ❌ is laid down --> ❌ formed.

In after wounding 2, there is ❌, and ❌ of normal cell adherence. There's ❌ of rete ridges, and cells slide over each other.

In granulation tissue 1, there is ❌ of CT elements, wound is ❌ and lost tissues are replaced by fibroblasts, venular ❌ multiply and bud off, whilst ❌ and platelet degradation products are ❌ for more inflammatory cells.

Granulation tissue 2 consist of from day 3 appearance of capillary buds and ❌. They then ❌ with others to flow, start to differentiate into arterioles and venules. Granulation 3 ❌ types 1 and 3 collagen. Early wound healing first makes ❌ acid and sulphated proteoglycans. Granulation tissue 4 consist of total amount of ❌ laid down by 3 weeks, and tensile strength of scar tissue increasing by the replacement of type 3 to type 1 collagen. There's a further ❌ in vascularity.