Lyme disease is caused by the bacterium Borrelia burgdorferi and is transmitted to humans through the bite of infected blacklegged ticks. B. burgdorferi can survive without iron, as it uses manganese in place of iron-sulfur clusters in its enzymes. Typical symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.
What type of reservoirs are involved in Lyme disease transmission?
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