Iron in Health and Disease

Pregunta 1 de 26

1

Forms of iron:
Ferric = ❌
Ferrous = ❌

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Fe2+

Fe3+

Explicación

Pregunta 2 de 26

1

There is no mechanism for iron excretion.

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FALSO

Explicación

Pregunta 3 de 26

1

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Approximately mg of iron is absorbed by the body per day.

Explicación

Pregunta 4 de 26

1

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Iron absorption occurs mainly in which part of the small bowel?
The

Explicación

Pregunta 5 de 26

1

Iron absorption is decreased by alcohol consumption.

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FALSO

Explicación

Pregunta 6 de 26

1

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Duodenal cytochrome B, found in the luminal surface, is responsible for ( reducing, oxidising ) ( ferric, ferrous ) iron to ( ferrous, ferric ) iron

Explicación

Pregunta 7 de 26

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is the main regulator of iron absorption. In cases of haemochromatosis, this structure binds to ferroportin and causes its degradation, thus disabling the transfer of iron to transferrin

Explicación

Pregunta 8 de 26

1

Assessment of body iron levels:
❌ = Measure Haemoglobin concentration
❌ = Measure % saturation of transferrin with iron
❌ = Measure serum ferritin

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Storage Iron

Transport Iron

Functional Iron

Regulated Iron

Explicación

Pregunta 9 de 26

1

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Transferrin has ( 2, 4, 6, 8 ) binding sites for iron

Explicación

Pregunta 10 de 26

1

❌ = Transferrin bound to iron
❌ = Transferrin not bound to iron

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Holotransferrin

Apotransferrin

Explicación

Pregunta 11 de 26

1

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Ferritin can store up to 4000 ( ferric, ferrous ) ions

Explicación

Pregunta 12 de 26

1

Which 4 of the follows factors can increase serum ferritin?

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Inflammation
Sepsis
Malignancy
Liver injury
Kidney Injury
Hypoxia
Anaemia

Explicación

Pregunta 13 de 26

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Name this clinical sign which can occur due to iron deficiency.

Explicación

Pregunta 14 de 26

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Iron deficiency can also cause inflammation and scarring of the corner of the mouth.
This sign is called

Explicación

Pregunta 15 de 26

1

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Iron deficiency causes a ( microcytic, macrocytic ) anaemia

Explicación

Pregunta 16 de 26

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There are greater requirements for iron in ( women and children, women, men, men and children ) thus they are more likely to develop iron deficiency.

Explicación

Pregunta 17 de 26

1

As well as poor dietary intake, which of the following can also cause iron deficiency anaemia?

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Menorrhagia
Gastric Ulcers
NSAIDs
Haematuria
Coeliac Disease
Ulcerative Colitis

Explicación

Pregunta 18 de 26

1

The two types of haemochromatosis are primary and secondary:
❌ haemochromatosis usually is the result of transfusions or iron loading anaemias.
❌ haemochromatosis is caused by a defect in the genes that control how much iron you absorb from food.

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Secondary

Primary

Explicación

Pregunta 19 de 26

1

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Hereditary Haemochromatosis is a primary haemochromatosis that typically arises due to a mutation of the HFE gene causing a decreased synthesis of which regulative protein?

Explicación

Pregunta 20 de 26

1

Haemochromatosis can cause erectile dysfunction in males

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Explicación

Pregunta 21 de 26

1

Which three of the following can be caused by haemochromatosis?

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Weakness/fatigue
Joint pains
Cirrhosis
Hypothyroidism
Cluster headaches
Trigeminal neuralgia

Explicación

Pregunta 22 de 26

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Hereditary Haemochromatosis most commonly occurs due to mutations in the gene

Explicación

Pregunta 23 de 26

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The initial treatment of choice for hereditary haemochromatosis in non-anaemic individuals is weekly

Explicación

Pregunta 24 de 26

1

The most common cause of death for those suffering from Hereditary Haemochromatosis is ...

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Diabetes
Hepatoma
Cardiac Failure

Explicación

Pregunta 25 de 26

1

Secondary Iron Overload should be treated with weekly venesection.

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VERDADERO
FALSO

Explicación

Pregunta 26 de 26

1

Primary Iron Overload. E.g. ❌. Should be treated with ❌
Secondary Iron Overload. E.g. ❌. Should be treated with ❌

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weekly venesection

iron chelating agents

Thalassaemia/Transfusion

Hereditary Haemochromatosis

	Creado por Matthew Coulson hace más de 5 años

Honours Degree (Haematology - Week 1) Medicine Test sobre Iron in Health and Disease, creado por Matthew Coulson el 02/03/2019.

Iron in Health and Disease

Iron in Health and Disease

Pregunta 1 de 26

Forms of iron: Ferric = ❌ Ferrous = ❌

Arrastra y suelta para completar el texto.

Explicación

Pregunta 2 de 26

There is no mechanism for iron excretion.

Selecciona uno de los siguientes:

Explicación

Pregunta 3 de 26

Rellena el espacio en blanco para completar el texto.

Approximately mg of iron is absorbed by the body per day.

Explicación

Pregunta 4 de 26

Rellena el espacio en blanco para completar el texto.

Iron absorption occurs mainly in which part of the small bowel? The

Explicación

Pregunta 5 de 26

Iron absorption is decreased by alcohol consumption.

Selecciona uno de los siguientes:

Explicación

Pregunta 6 de 26

Selecciona la opción correcta de los menús desplegables para completar el texto.

Duodenal cytochrome B, found in the luminal surface, is responsible for reducing oxidising( reducing, oxidising ) ferric ferrous( ferric, ferrous ) iron to ferrous ferric( ferrous, ferric ) iron

Explicación

Pregunta 7 de 26

Rellena el espacio en blanco para completar el texto.

is the main regulator of iron absorption. In cases of haemochromatosis, this structure binds to ferroportin and causes its degradation, thus disabling the transfer of iron to transferrin

Explicación

Pregunta 8 de 26

Assessment of body iron levels: ❌ = Measure Haemoglobin concentration ❌ = Measure % saturation of transferrin with iron ❌ = Measure serum ferritin

Arrastra y suelta para completar el texto.

Explicación

Pregunta 9 de 26

Selecciona la opción correcta del menú desplegable para completar el texto.

Transferrin has 2 4 6 8( 2, 4, 6, 8 ) binding sites for iron

Explicación

Pregunta 10 de 26

❌ = Transferrin bound to iron ❌ = Transferrin not bound to iron

Arrastra y suelta para completar el texto.

Explicación

Pregunta 11 de 26

Selecciona la opción correcta del menú desplegable para completar el texto.

Ferritin can store up to 4000 ferric ferrous( ferric, ferrous ) ions

Explicación

Pregunta 12 de 26

Which 4 of the follows factors can increase serum ferritin?

Selecciona una o más de las siguientes respuestas posibles:

Explicación

Pregunta 13 de 26

Rellena el espacio en blanco para completar el texto.

Name this clinical sign which can occur due to iron deficiency.

Explicación

Pregunta 14 de 26

Rellena el espacio en blanco para completar el texto.

Iron deficiency can also cause inflammation and scarring of the corner of the mouth. This sign is called

Explicación

Pregunta 15 de 26

Selecciona la opción correcta del menú desplegable para completar el texto.

Iron deficiency causes a microcytic macrocytic( microcytic, macrocytic ) anaemia

Explicación

Pregunta 16 de 26

Selecciona la opción correcta del menú desplegable para completar el texto.

There are greater requirements for iron in women and children women men men and children( women and children, women, men, men and children ) thus they are more likely to develop iron deficiency.

Explicación

Pregunta 17 de 26

As well as poor dietary intake, which of the following can also cause iron deficiency anaemia?

Selecciona una o más de las siguientes respuestas posibles:

Explicación

Pregunta 18 de 26

The two types of haemochromatosis are primary and secondary: ❌ haemochromatosis usually is the result of transfusions or iron loading anaemias. ❌ haemochromatosis is caused by a defect in the genes that control how much iron you absorb from food.

Arrastra y suelta para completar el texto.

Explicación

Pregunta 19 de 26

Rellena el espacio en blanco para completar el texto.

Hereditary Haemochromatosis is a primary haemochromatosis that typically arises due to a mutation of the HFE gene causing a decreased synthesis of which regulative protein?

Explicación

Pregunta 20 de 26

Forms of iron:
Ferric = ❌
Ferrous = ❌

Iron absorption occurs mainly in which part of the small bowel?
The

Duodenal cytochrome B, found in the luminal surface, is responsible for ( reducing, oxidising ) ( ferric, ferrous ) iron to ( ferrous, ferric ) iron

Assessment of body iron levels:
❌ = Measure Haemoglobin concentration
❌ = Measure % saturation of transferrin with iron
❌ = Measure serum ferritin

Transferrin has ( 2, 4, 6, 8 ) binding sites for iron

❌ = Transferrin bound to iron
❌ = Transferrin not bound to iron

Ferritin can store up to 4000 ( ferric, ferrous ) ions

Iron deficiency can also cause inflammation and scarring of the corner of the mouth.
This sign is called

Iron deficiency causes a ( microcytic, macrocytic ) anaemia

There are greater requirements for iron in ( women and children, women, men, men and children ) thus they are more likely to develop iron deficiency.

The two types of haemochromatosis are primary and secondary:
❌ haemochromatosis usually is the result of transfusions or iron loading anaemias.
❌ haemochromatosis is caused by a defect in the genes that control how much iron you absorb from food.

Primary Iron Overload. E.g. ❌. Should be treated with ❌
Secondary Iron Overload. E.g. ❌. Should be treated with ❌