Philadelphia Chromosome is most associated with which form of Leukaemia?
Chronic Myeloid Leukaemia is fatal without stem cell/bone marrow transplantation in the chronic phase
Which of the following conditions can in some cases present as Gout?
Acute Myeloid Leukaemia
Acute Lymphoblastic Leukaemia
Chronic Lymphoblastic Leukaemia
Chronic Myeloid Leukaemia
Which of the following would describe findings fitting with a diagnosis of Chronic Myeloid Leukaemia?
Neutrophilia, Eosinophilia, Basophilia, Thrombocytosis
Neutropenia, Eosinopenia, Basopenia, Thrombocytopenia
❌ - Causes a drastic rise in erythrocytes, platelets, neutrophils, etc ❌ - Causes a drastic fall in erythrocytes, platelets, neutrophils, etc
Philadelphia Chromosome causes expression of a new gene encoding a protein kinase. Which of the following protein kinase inhibitors can be used to successfully treat Chronic Myeloid Leukaemia?
Tyrosine Kinase Inhibitors
Protein Kinase A Inhibitors
Protein Kinase G Inhibitors
Protein Kinase C Inhibitors
Tyramine Kinase Inhibitors
The main tyrosine kinase inhibitor used to treat chronic myeloid leukaemia is called
A patient presents to their GP complaining of headache, fatigue and an intense itching which only ever occurs whilst in the bath or shower. Their blood results show high haemoglobin levels accompanied by erythrocytosis (increase in circulating RBCs). What is your working diagnosis?
The presence of a JAK2 mutation in a patient would immediately lead you to thinking of which Myeloproliferative disorder?
The main treatment for polycythaemia rubra vera is regular
The treatment for Polycythaemia Rubra Vera is venesection until the haematocrit falls below 0.45 0.55 0.65 0.35( 0.45, 0.55, 0.65, 0.35 )
An uncontrolled production of abnormal platelets is known as Essential
Essential Thrombocythaemia causes excessive bleeding problems
Teardrop-shaped Red Blood Cells in the peripheral blood is characteristic of which Myeloproliferative Disorder?
Idiopathic Myelofibrosis
Essential Thrombocythaemia
Polycythaemia Rubra Vera
Idiopathic is a condition in which the proliferation of an abnormal clone of a hematopoietic stem cell results in fibrosis, or the replacement of bone marrow with scar tissue
Myelofibrosis typically results in hepatomegaly
What is the first line treatment for essential thrombocythaemia?
Interferon Gamma
Interferon Beta
Hydroxycarbamide
Aspirin
Clopidogrel
Which of the following can be used as a secondary therapy for Essential Thrombocythaemia?
Interferon Alpha
Chronic Haemolysis predisposes an individual to gallstones
Chronic haemolysis predisposes to gallstones as there are raised levels of in the blood
