Mer Scott
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(Oncology) PHCY320 Test sobre ON11 Leukemia & Lymphoma​, creado por Mer Scott el 07/10/2019.

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ON11 Leukemia & Lymphoma​

Pregunta 1 de 15

1

Leukemias​ - cancer of the body's blood-forming tissues:
Acute Myeloid Leukemia​
Chronic Myeloid Leukemia​
Acute Lymphocytic Leukemia​
Chronic Lymphocytic Leukemia​
Note: Acute leukemia involves the immature cells, called cells, whereas chronic leukemia develops in cells. Myeloid = bone marrow and , lymphocytic = .

Lymphomas​(cancer beginning in lymphocytes)
- Non-Hodgkin’s Lymphoma
More , more likely to be in older patients. Begins in nodes.
- Hodgkin’s Lymphoma ​
Hodgkin's lymphoma is marked by the presence of cells, which a physician can identify using a microscope. In Non-Hodgkin lymphoma, these cells are not present. Typically begins in the body, such as the neck, chest or armpits.

Arrastra y suelta para completar el texto.

    stem
    mature
    RBCS
    WBCs
    common
    any
    Reed-Sternberg
    upper

Explicación

Pregunta 2 de 15

1

Choose the incorrect epidemiology statement.

Selecciona una de las siguientes respuestas posibles:

  • Blood cancers combined are the 5th most common cancer in NZ​

  • Lymphoma most common in 35-50 year olds​

  • Leukemia most common childhood cancer​

  • 21,000 people living with blood cancers in NZ​

Explicación

Pregunta 3 de 15

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Which of these is not a risk factor for leukemia?

Selecciona una de las siguientes respuestas posibles:

  • Previous cancer treatment​

  • Genetic disorders​

  • Exposure to certain chemicals​

  • Smoking​

  • Family history ​

  • Young

Explicación

Pregunta 4 de 15

1

Select ALL the risk factors for NON-Hodgkin's lymphoma.

Selecciona una o más de las siguientes respuestas posibles:

  • Previous infection with EBV​

  • Weak immune system​

  • Family history​

  • Chemical exposures​

  • Previous chemo or radiation​

  • Immune deficiency / HIV​

Explicación

Pregunta 5 de 15

1

There are no widely recommended screening tests​ for leukemias and lymphomas but they may be identified through routine bloodwork.

Selecciona uno de los siguientes:

  • VERDADERO
  • FALSO

Explicación

Pregunta 6 de 15

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Clinical Presentation:
Coughing / pain​
Fever / chills​
Frequent
skin or rash​

Loss of or nausea​
sweats​
Persistent and fatigue​
Shortness of
, painless lymph nodes in neck, armpits, or groin ​

Arrastra y suelta para completar el texto.

    chest
    infections
    Itchy
    appetite
    Night
    weakness
    breath
    Swollen

Explicación

Pregunta 7 de 15

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Leukemia diagnosis:
- Signs and symptoms​
- Complete
- biopsy

Lymphoma diagnosis:
- Signs and symptoms​
- biopsy/extraction​
- Complete blood cell count​
- Bone marrow biopsy​
- (look for signs in other parts of your body)​

Arrastra y suelta para completar el texto.

    blood cell count​
    Bone marrow
    Lymph Node
    Imaging

Explicación

Pregunta 8 de 15

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Prognosis​:

Leukemia -
Children (ALL) - % cured​
Adults (ALL) - % achieve remission​
Adults (AML) - % achieve remission​
+ 70% 5-year survival ALL​.

Lymphoma:
HL - 5-year survival
NHL​:
Localized -
Regional - 72%​
Distant -

Arrastra y suelta para completar el texto.

    90
    80-90
    60-70
    86%​
    72%​
    55%​

Explicación

Pregunta 9 de 15

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Treatment – Acute Lymphocytic Leukemia.
1. Induction of remission - [, +/- ]​ = 1-2 months​
2. Consolidation (intensification) [same drugs, high doses]​ = months​
3. Maintenance [, +/- imatinib]​ = 2

CNS treatment/prophylaxis (may be continued through all phases)​:
Intrathecal [methotrexate]​
High dose methotrexate​

Arrastra y suelta para completar el texto.

    vincristine, steroid, anthracycline
    imatinib
    2-4
    methotrexate, 6MP
    years
    Radiation
    IV

Explicación

Pregunta 10 de 15

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Treatment – Chronic Lymphocytic Leukemia​:

Watch and
Once symptoms appear / disease progressing:​ Many different combinations of standard used, in addition to therapy, and/or monoclonal antibodies []​.
HSCT (Stem Cell Transplants) a possibility for high risk patients.

Arrastra y suelta para completar el texto.

    wait
    chemotherapy
    targeted
    rituximab, imatinib

Explicación

Pregunta 11 de 15

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Treatment – Non-Hodgkin’s Lymphoma​
Chemotherapy – cycles of combination therapy over several months​:
- [Cyclophosphamide, Doxorubicin, Vincristine, Prednisone]​
- R-CHOP [add if CD20 positive]​
- [Cyclophosphamide, Vincristine, Prednisone]​
- [Ifostamide, Carboplatin, Etoposide]​

Radiation and HSCT are also options for high risk patients .

Arrastra y suelta para completar el texto.

    6-8
    CHOP
    Rituximab
    CVP
    ICE

Explicación

Pregunta 12 de 15

1

Select all drugs in the CHOP chemo combo.

Selecciona una o más de las siguientes respuestas posibles:

  • Cyclophosphamide

  • Doxorubicin

  • Docetaxel

  • Vincristine

  • Prednisone

  • Cisplatin

Explicación

Pregunta 13 de 15

1

Monitoring intrathecal CT:
- Every , check symptoms - Headache, changes, fatigue, issues, soreness/ at entry​?
- labs for blood cell
- Check for signs of infection

Arrastra y suelta para completar el texto.

    dose
    visual
    balance
    bruise
    Weekly
    count
    daily

Explicación

Pregunta 14 de 15

1

What are the signs/symptoms of Febrile Neutropenia?

Selecciona una de las siguientes respuestas posibles:

  • Fever (>38.3 C or > 38.0 C over 1 hour) ​and ANC <500 cells/mm^3 ​

  • Fatigue/weakness ANC <500 cells/mm^3 ​

  • Fever (>38.3 C or > 38.0 C over 1 hour) ​and ANC <300 cells/mm^3 ​

  • Fatigue/weakness ANC <300 cells/mm^3 ​

Explicación

Pregunta 15 de 15

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Watch and wait is an appropriate strategy for which type of blood cancer?

Selecciona una de las siguientes respuestas posibles:

  • Hodgkin’s Lymphoma

  • Chronic Lymphocytic Leukemia​

  • Acute Myeloid Leukemia​

Explicación