Inflammation and Wound Healing - L6-7

Pregunta 1 de 24

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How do you describe an organ that is inflamed?

= inflammation of that tissue

Explicación

Pregunta 2 de 24

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Acute Inflammation

Selecciona una o más de las siguientes respuestas posibles:

mediated by Interleukin-1 and other cytokines
Systemic response to severe injury or inflammation
To over come the cause of Inflammation (occurring after the other type of inflammation fails)
Walls off area with fibrous connective tissue

Explicación

Pregunta 3 de 24

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Chronic Inflammation

Selecciona una o más de las siguientes respuestas posibles:

Walls off the area with fibrous connective tissue
Mediated by Interleukin-1 and other cytokines
Systemic response to severe injury or inflammation
To over come the cause of Inflammation (occurring after the other type of inflammation fails)

Explicación

Pregunta 4 de 24

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What are the five classical signs associated with Inflammation?
1.
2.
3.
4.
5.

Explicación

Pregunta 5 de 24

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Changes occurring during the vascular phase of acute inflammation

1. ❌
Capillary beds ❌
Signs associated: ❌ and ❌

2. ❌
Chemical mediators are released ❌
Fluid flows through the ❌
Signs associated: ❌

3. ❌
Blood is more ❌ - ❌ the flow
Increase in ❌ and ❌ in the area

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Vasodilation of arterioles

Contraction of endothelial cells

Leakage of Fluid

viscous

Heat

Redness

gaps into the extracellular space

Swelling

Slows

RBC

WBC

causing contraction of endothelial cells

distend with blood

Explicación

Pregunta 6 de 24

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Functions of the vascular phase

1.
2.
3.
4.

Explicación

Pregunta 7 de 24

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Changes occurring during the cellular phase of inflammation

1. ❌
Slowing of blood during the vascular phase - leukocytes contact endothelial cells

2. ❌
2a. ❌
2b. ❌
2c. ❌ and ❌
2d. ❌
2e. ❌

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Margination

Emigration

Tethering

Rolling

Activation

firm adhesion

Transmigration

Chemotaxis

Explicación

Pregunta 8 de 24

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Functions of the cellular phase

1.
2.
3. to
4.

Explicación

Pregunta 9 de 24

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What are the Leukocytes associated with inflammation?

1.
2.
3.

Explicación

Pregunta 10 de 24

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What are the four different inflammatory exudates?

1. ❌ exudate
❌, low in ❌

2. ❌ Inflammation
Fibrinogen --> ❌
❌ present

3. ❌ Inflammation
Mucus
Due to inflammation of ❌

4. ❌ or ❌ Inflammation
❌
Lot of ❌, ❌ and ❌

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Serous

Watery fluid

protein

clots

Neutrophils

Catarrhal

mucous membranes

Suppurative

Purulent

Pus

neutrophils

fluid

necrotic debris

Fibrinous

Explicación

Pregunta 11 de 24

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What is the purpose of inflammatory mediators?

Be the that , or inflammation

Explicación

Pregunta 12 de 24

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Demolition Phase

What: The ❌ after the fluid and cellular phases

Processes occurring: ❌ and ❌

Processes function: To ❌

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breakdown and removal of necrotic tissue

Liquefaction

Phagocytosis

prepare for repair and regeneration

Explicación

Pregunta 13 de 24

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What are the outcomes of acute inflammation?

1.
If injury is and there is
Damage is or

2.
OR occurs when there is lots of tissue destruction or they cant regenerate

3.
If the cause of OR
Something

Explicación

Pregunta 14 de 24

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Four phases of wound healing

1. ❌
AIM: ❌ ❌
❌ --> ❌ --> ❌

2. ❌
❌ present
❌ remove ❌

3. ❌ & ❌
AIM: ❌
❌ produce ❌ --> ❌ of epi. cells and fibroblasts
Granulation tissue = ❌

4. ❌
Once inflammation finished & new tissue forms - ❌ ❌

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Homeostasis

Acute Inflammation

Granulation tissue formation

replacement of epithelial tissue cells

Wound maturation and Remodeling

To prevent further bleeding

by blood clotting

Vessel constriction

Platelet plug

Fibrin plug

Classical signs of inflammation

Neutrophils and Macrophages

debris from injury

Fill in gap of damaged tissue

fibrous connective tissue + capillaries

granulation tissue is replaced by mature

connective tissue

macrophages

growth factors

proliferation

Explicación

Pregunta 15 de 24

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Healing by First Intention
+

Occurs if:
Minimal
Minimal

Explicación

Pregunta 16 de 24

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Healing by second intention
- , ,

Occurs when:
Greater

Wound edges
present

Explicación

Pregunta 17 de 24

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Process of wound contraction
Feature of ❌
Wound margins ❌

- ❌ ❌
- ❌ ❌
- Continues ❌

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2nd Intention

grow towards each other

Myofibroblasts at edges contract

bringing edges together

Makes smaller wound to fill with

granulation tissue and epithelial cells

after re-epithelialisation

Explicación

Pregunta 18 de 24

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Factors affecting wound healing

1.
2.
3.
4.
5.
6.

Explicación

Pregunta 19 de 24

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What are the events involved in fracture repair?
1.
2.
3.
4.

Explicación

Pregunta 20 de 24

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What are the factors that affect fracture healing?

1.
2.
3.

Explicación

Pregunta 21 de 24

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Antigen:
substance that or

Antibody:
in response to or

Explicación

Pregunta 22 de 24

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Hypersensitivity reactions P1

Type I = ❌ Hypersensitivity
Due to ❌
Occurs within ❌
Reactions directed against ❌
activation of ❌, ❌ & ❌
Mediators that cause: ❌, ❌ --> ❌, ❌

E.g ❌ (Hay fever)

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Immediate

IgE antibodies

minutes of repeat exposure

seconds of repeat exposure

antigens from enviro & parasites

mast cells

basophils

eosinophils

smooth muscle spasm

oedema

swelling

excessive mucus secretion

Allergic Rhinitis

Rhinitis Allergic

Explicación

Pregunta 23 de 24

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Hypersensitivity reactions P2

Type II = ❌ hypersensitivity
Formation of ❌ of the ❌
Leads to the ❌

E.g. ❌

Type III = ❌ hypersensitiviity
Occurs due to ❌ ❌
These ❌
Neutrophils release ❌ into tissue - damage tissue
commonly occurs in the ❌, ❌, ❌ and ❌

E.g. ❌ (SLE)

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Antibody mediated

Immune complex

Immune mediated haemolytic anaemia

Lupus

antibodies directed against antigens

surface of a cell or tissue

cell being destroyed

formation of antigen-antibody complexes

in bloodstream

get stuck in capillaries

toxic free radicals and enzymes

joints

glomeruli

eye

blood vessels

Explicación

Pregunta 24 de 24

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	Creado por Hannah-Marie Rhodes hace más de 4 años

Pathology Test sobre Inflammation and Wound Healing - L6-7, creado por Hannah-Marie Rhodes el 12/02/2020.

Inflammation and Wound Healing - L6-7

Pregunta 1 de 24

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How do you describe an organ that is inflamed? = inflammation of that tissue

Explicación

Pregunta 2 de 24

Acute Inflammation

Selecciona una o más de las siguientes respuestas posibles:

Explicación

Pregunta 3 de 24

Chronic Inflammation

Selecciona una o más de las siguientes respuestas posibles:

Explicación

Pregunta 4 de 24

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What are the five classical signs associated with Inflammation? 1. 2. 3. 4. 5.

Explicación

Pregunta 5 de 24

Changes occurring during the vascular phase of acute inflammation 1. ❌ Capillary beds ❌ Signs associated: ❌ and ❌ 2. ❌ Chemical mediators are released ❌ Fluid flows through the ❌ Signs associated: ❌ 3. ❌ Blood is more ❌ - ❌ the flow Increase in ❌ and ❌ in the area

Arrastra y suelta para completar el texto.

Explicación

Pregunta 6 de 24

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Functions of the vascular phase 1. 2. 3. 4.

Explicación

Pregunta 7 de 24

Changes occurring during the cellular phase of inflammation 1. ❌ Slowing of blood during the vascular phase - leukocytes contact endothelial cells 2. ❌ 2a. ❌ 2b. ❌ 2c. ❌ and ❌ 2d. ❌ 2e. ❌

Arrastra y suelta para completar el texto.

Explicación

Pregunta 8 de 24

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Functions of the cellular phase 1. 2. 3. to 4.

Explicación

Pregunta 9 de 24

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What are the Leukocytes associated with inflammation? 1. 2. 3.

Explicación

Pregunta 10 de 24

What are the four different inflammatory exudates? 1. ❌ exudate ❌, low in ❌ 2. ❌ Inflammation Fibrinogen --> ❌ ❌ present 3. ❌ Inflammation Mucus Due to inflammation of ❌ 4. ❌ or ❌ Inflammation ❌ Lot of ❌, ❌ and ❌

Arrastra y suelta para completar el texto.

Explicación

Pregunta 11 de 24

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What is the purpose of inflammatory mediators? Be the that , or inflammation

Explicación

Pregunta 12 de 24

Demolition Phase What: The ❌ after the fluid and cellular phases Processes occurring: ❌ and ❌ Processes function: To ❌

Arrastra y suelta para completar el texto.

Explicación

Pregunta 13 de 24

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What are the outcomes of acute inflammation? 1. If injury is and there is Damage is or 2. OR occurs when there is lots of tissue destruction or they cant regenerate 3. If the cause of OR Something

Explicación

Pregunta 14 de 24

Four phases of wound healing 1. ❌ AIM: ❌ ❌ ❌ --> ❌ --> ❌ 2. ❌ ❌ present ❌ remove ❌ 3. ❌ & ❌ AIM: ❌ ❌ produce ❌ --> ❌ of epi. cells and fibroblasts Granulation tissue = ❌ 4. ❌ Once inflammation finished & new tissue forms - ❌ ❌

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Explicación

Pregunta 15 de 24

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Healing by First Intention + Occurs if: Minimal Minimal

Explicación

Pregunta 16 de 24

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Healing by second intention - , , Occurs when: Greater Wound edges present

Explicación

Pregunta 17 de 24

Process of wound contraction Feature of ❌ Wound margins ❌ - ❌ ❌ - ❌ ❌ - Continues ❌

Arrastra y suelta para completar el texto.

Explicación

Pregunta 18 de 24

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Factors affecting wound healing 1. 2. 3. 4. 5. 6.

Explicación

Pregunta 19 de 24

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What are the events involved in fracture repair? 1. 2. 3. 4.

Explicación

Pregunta 20 de 24

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How do you describe an organ that is inflamed?

= inflammation of that tissue

What are the five classical signs associated with Inflammation?
1.
2.
3.
4.
5.

Changes occurring during the vascular phase of acute inflammation

1. ❌
Capillary beds ❌
Signs associated: ❌ and ❌

2. ❌
Chemical mediators are released ❌
Fluid flows through the ❌
Signs associated: ❌

3. ❌
Blood is more ❌ - ❌ the flow
Increase in ❌ and ❌ in the area

Functions of the vascular phase

1.
2.
3.
4.

Changes occurring during the cellular phase of inflammation

1. ❌
Slowing of blood during the vascular phase - leukocytes contact endothelial cells

2. ❌
2a. ❌
2b. ❌
2c. ❌ and ❌
2d. ❌
2e. ❌

Functions of the cellular phase

1.
2.
3. to
4.

What are the Leukocytes associated with inflammation?

1.
2.
3.

What are the four different inflammatory exudates?

1. ❌ exudate
❌, low in ❌

2. ❌ Inflammation
Fibrinogen --> ❌
❌ present

3. ❌ Inflammation
Mucus
Due to inflammation of ❌

4. ❌ or ❌ Inflammation
❌
Lot of ❌, ❌ and ❌

What is the purpose of inflammatory mediators?

Be the that , or inflammation

Demolition Phase

What: The ❌ after the fluid and cellular phases

Processes occurring: ❌ and ❌

Processes function: To ❌

What are the outcomes of acute inflammation?

1.
If injury is and there is
Damage is or

2.
OR occurs when there is lots of tissue destruction or they cant regenerate

3.
If the cause of OR
Something

Four phases of wound healing

1. ❌
AIM: ❌ ❌
❌ --> ❌ --> ❌

2. ❌
❌ present
❌ remove ❌

3. ❌ & ❌
AIM: ❌
❌ produce ❌ --> ❌ of epi. cells and fibroblasts
Granulation tissue = ❌

4. ❌
Once inflammation finished & new tissue forms - ❌ ❌

Healing by First Intention
+

Occurs if:
Minimal
Minimal

Healing by second intention
- , ,

Occurs when:
Greater

Wound edges
present

Process of wound contraction
Feature of ❌
Wound margins ❌

- ❌ ❌
- ❌ ❌
- Continues ❌

Factors affecting wound healing

1.
2.
3.
4.
5.
6.

What are the events involved in fracture repair?
1.
2.
3.
4.

What are the factors that affect fracture healing?

1.
2.
3.

Antigen:
substance that or

Antibody:
in response to or

Hypersensitivity reactions P1

Type I = ❌ Hypersensitivity
Due to ❌
Occurs within ❌
Reactions directed against ❌
activation of ❌, ❌ & ❌
Mediators that cause: ❌, ❌ --> ❌, ❌

E.g ❌ (Hay fever)

Hypersensitivity reactions P2

Type II = ❌ hypersensitivity
Formation of ❌ of the ❌
Leads to the ❌

E.g. ❌

Type III = ❌ hypersensitiviity
Occurs due to ❌ ❌
These ❌
Neutrophils release ❌ into tissue - damage tissue
commonly occurs in the ❌, ❌, ❌ and ❌

E.g. ❌ (SLE)

Immunological Test
Measures - checks the
E.g.

Serological Test
Based on the ability to detect reactions from the
E.g. S