L8-Neurotransmitter identification and proof of function **

Neurotransmitters:
Established (we know they are neurotransmitters and what they do)

Neurotransmitters:
Putative- unsure if neurotransmitters or not

Steps in establishing a neurotransmitter

7 criteria for a neurotransmitter

Noradrenaline- establishment as a neurotransmitter:
Identification of biological activity

Noradrenaline: identification of active principle

Noradrenaline: presence in the nerve

Noradrenaline;
synthesis in nerve

Noradrenaline: storage in the nerve

Noradrenaline:
release from the nerve

Noradrenaline:
activation of specific receptors

Noradrenaline: mechanism for swift termination of action

Summary:
Noradrenaline as an established neurotransmitter

Importance of identifying transmitters

Drugs developed from knowledge about noradrenaline