Motor unit

Neuromuscular junction structure
- schwann cell forms lid over junctional cleft
-membrane thrown into junctional folds to increase SA
- acetylcholine diffuses through junctional cleft

How drugs can modify synaptic (neuromuscular) transmission

Key steps in neuromuscular transmission

Prejunctional events of neuromuscular transmission

Drugs acting prejunctionally to inhibit neuromuscular transmission

Post-junctional events in neuromuscular transmission

The nicotinic ach receptor

Drugs acting postjunctionally to inhibit neuromuscular transmission

Clinical uses of reversible competitive antagonists

Depolarising muscle relaxants

Anticholinestherase drugs