Rational Use of Drugs

Therapeutic Range

Steady-State Plasma Drug Concentration

Dosing Regimen

Pharmacokinetics

Plasma Concentration-Time Profile of A Drug

BIOAVAILABILITY

AUC
(area under the plasma concentration versus time curve)

Clearance (CL)

Steady state

Volume of Distribution (V)

Clinical use of Volume of Distribution

Loading Dose

Half-life (t1/2)

Half-life is a major determinant of the ff.

First order kinetics

SATURABLE METABOLISM

Zero-order Kinetics