Toxicology - genotoxic compounds and cancer

Excision repair

Hur repareras DNA om en bas reagerer och ändrar struktur under replikationen?

Destabilation of DNA bases

Cross-linking of DNA

Intercalation

2 mutation classes

Baspair substitution

Frame shift mutation

Chromosome mutations

Effects of mutations

A classical scenario for the development of cancer

Characteristic of cancer cells

Benign

Malignant

Carcinogenic

Genotoxic carcinogens

Epigenetic carcinogens

Oncogenes

Protooncogenes

Antioncogenes

Oncogenes’ proteins

Cancer can form when

Dominant and recessive mutations