medical pharmacology and PPT

What is pharmacodynamics

what is pharmacokinetics

strength of binding of drug to receptor is called what?

selectivity of drug to bind to receptor is called what?

which drug abolishes anticoagulant effect of heparin

what time of decay to most drugs have from the blood stream

how are most drugs eliminated

How to increase rate of aspirin renal excretion

Liver phase I reaction

liver phase II reaction

drugs that are enzyme inducers

Cimetidine inhibits the metabolism of which drugs

erythromycin inhibits the metabolism of which drugs

General MOA or local anaesthetics and some examples

Unwanted effects of local anaesthetics

examples of acetylcholiesterases and what they are used to treat

what to use edrophonium for

neuromuscular blocking drugs

neuromuscular blocking drug to use in severe renal or liver failure

what are cholinomimetics

Alpha 2 blocker examples and MOA

What does phenylephrine do?

alpha 1 blocker name and use

What to MAO and COMT do

what does activation of alpha adrenoreceptors lead to

What does activation of alpha 2 adrenoreceptors do

How to indirect sympathomimetics work and examples

beta blockers

cardioselective beta blockers and asthma?

how to reduce pressure in glaucoma

which drug classes cause mydriasis

Drugs to cause miosis

Corticosteroid effect on the eye (bad)

Recommended safe dose of lidocaine 1% and bupivicaine 0.25%

Max single dose of lidocaine 1% and bupivicaine 0.25%

Centor criteria

Mecahnisms of drug resistance

drug resistant organisms of concern in the UK

Definition of sepsis
severe sepsis
septicv shock

What is sepsis 6

How is MRSA and most antibiotic resistance transmitted

Methiclillin resistance equates to which antibiotic

what would you prescribe in methicillin resistance

What can we do to prevent infections with resistant organisms

ECO risk of drugs, high, intermediate, low

Phenytoin precipitates in dextrose solutions
Amphotericin precipitates in saline
Gentamicin is physically/chemically incompatible with most beta-lactams

these are examples of what type of drug interaction

sucrulfate, some milk products, antacids and oral iron preparations block absorption of what

Omeprazole, lansoprazole andH2 antagonists reduce absorption of what?

Colestyramine binds which drugs

Cytochrome p450 3A4 responsible for metabolism of:

inhibitors and inducers of CYP450 3A4

CYP2D6 metabolism of what and inhibited by what

Cytochrome p450 2c9

cyp 2c19

Cyp1A2

examples of drug food interactions

grapefruit and statins

St Johns wort

Drug interactions with anti-retrovirals

what does cooling blood samples do to potassium levels

Hypokalaemic, hypernatraemia

cause of coma in severe type 2 diabetes

tumour markers

some random points to remember

Type A (augmented) drug reaction

Type B (bizzare) drug reaction

Other drug reactions

Type C (Chronic treatment effects) osteoporosis with steroids

Type D (Delayed effects)
drug induced cancers

Type E (End of treatment effects) withdrawal syndromes

other type A drug reactions

Mechanisms of type B idiosyncratic drug reactions

Hx of anaphylaxis, urticaria or rash immediately after penicillin

penicillin allergy, do not use any of the following

don't use flucloxacillin in which type of disorder

cyclophosphamide class and specific side effects

Methotrexate class and specific side effects

Docorubicin class and specific side effects

5-FU class and specific side effects

Side effects and common drugs
Nausea and vom
alopecia
hyperuricaemia
neurtropaenia

often drug causes conditions
anaphylaxis
stevens-johnson syndrome
blood dyscrasias

highly protein bound drugs and factors which can affect that

Liver disease leads to hiugh concentrations of what

things that interfere with the pill

drugs with high renal excretion

lithium adverse effects

helicobacter eradication triple therapy

drugs in UC and Chron's

5ht4 receptor agonist for chronic constipation

GCC agonist

side effects of beta blockers

angina treatments

angina vasodilators

site of action of diuretics

Loop diuretics

Thiazide diuretics

potassium sparing diuretics

ACEi/ARB

PPT notes on arrhythmias

amiodarone side effects

Digoxin

Warfarin

who to anticoagulate

newer anticaogulants

antiplatelets

Clinical used of antiplatelets

Dopamine theory in schizophrenia

drugs used post MI

1st vs 2nd gen antipsychotics

Aripiprazole

treatment resistant schizophrenia

Treatment of bipolar

Mood stabilisers

depression treatment resistance

Venlafaxine and duloxetine

NaSSA

MAO-I

What to do in TCA overdose

when to use acetylcysteine

What can you get in acetylcystein

Charcoal

Multiplke dose axctivated charcoaal in what

Drugs not absorbed by activated charcoal

Guidelines on order of neuropathic pain meds

UTI, what drug to avoid

Tuberculosis drugs MOA and side effects

eye drops to anaesthetise the eye

Short acting drug use to diagnose myasthenia gravis

side effects of competitive neuromuscular blocking drugs

Name of the depolarising neuromuscular blocking drug and its main disadvantage

What drug to use in BPH and how does it work

Drugs that decrease IOP by increasing outflow

Drugs that reduce IOP by decreasing aqueous secretion other than B blocker

drugs to treat wet age released macular degeneration

Side effects of theophylline

which histamine in allergy and which in GI

Which GI drug can cause gynaecomastia and can bind to cytochrome -450 to reduce metabolism of warfarin, phenytoin and theophylline

example peptic ulcer disease regimes

name the 4 types of laxative, give examples and how they work

ulcerative colitis vs Crohn's - inducing remission and maintenance

side effects of bendroflumethiazide

In renal impairment, which of thiazides or loop diuretics are effective

side effects of loop diuretics

names of K+ sparing diuretics, MOA, side effects

a good cardioselective beta blocker to use in hypertension

management of acute severe hypertension

Side effects of nitrates

pharmacological management of bradycardia post MI

Drugs used in supra ventricular arrhythmias

Drugs effective in SVT and Ventricular arrhythmias

Drugs used in ventricular arrhythmias

How to assess cardiovascular risk
How to reduce also

Which classes (and give examples of drugs) can be used to reduce nausea and vomiting of motion sickness

How to treat vertigo and vomiting associated with vestibular disease

Good combination of drugs to prevent chemo induced emesis

Specific antiemetic to use in Meniere's disease

name the 2 classes of steroid hormones, examples and where they are made

What types of insulin are these: Insulin deter, Insulin glargine

What type of insulin is isophane insulin

What type of insulins are these: Insulin lispro, insulin apart, insulin glulisine

What is co-trimoxazole?

and a specific bacteria is is good with

good drug to use for analgesia when you want to avoid morphine associated sphincter spasm

give examples of GnRH agonists, what they are used in and how they work

Which two conditions is clopidogrel first line anti platelet therapy for

who should receive a statin