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Comprehensive Review questions compiled by turknO_ for leggomed

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BIOCHEMISTRY: Intermediate metabolism

Pregunta 1 de 20

1

A low level of carbon dioxide labeled with 14C is accidentally released into the atmosphere surrounding industrial workers as they resume work following the lunch hour. Unknowingly, they breathe the contaminated air for 1 hour. Which of the following compounds will be radioactively labeled?

Selecciona una de las siguientes respuestas posibles:

  • All of the carbon atoms of newly synthesized fatty acid.

  • About one half of the carbon atoms of newly synthesized fatty acids.

  • The carboxyl atom of newly synthesized fatty acids.

  • About one third of the carbons of newly synthesized malonyl CoA.

  • One half of the carbon atoms of newly synthesized acetyl CoA.

Explicación

Pregunta 2 de 20

1

A teenager, concerned about his weight, attempts to maintain a fat-free diet for a period of several weeks. If his ability to synthesize various lipids were examined, he would be found to be most deficient in his ability to synthesize:

Selecciona una de las siguientes respuestas posibles:

  • Triacylglycerol

  • Phospholipids

  • Cholesterol

  • Sphingolipids

  • Prostaglandins

Explicación

Pregunta 3 de 20

1

A 44-year-old man displayed elevated cholesterol levels and was prescribed a statin to reduce such levels. Statin treatment has the potential to interfere with the synthesis of which of the following?

Selecciona una de las siguientes respuestas posibles:

  • Heme

  • Dihydrobiopterin

  • Ketone bodies

  • Coenzyme Q

  • Glycogen

Explicación

Pregunta 4 de 20

1

A 12-year-old female presented with severe abdominal pain and was found to have a markedly elevated plasma triglyceride concentration (750 mg/dL). A lipoprotein analysis revealed elevated levels of chylomicrons and VLDL and reduced levels of HDL. Which protein might be defective in this patient?

Selecciona una de las siguientes respuestas posibles:

  • ApoCII

  • ApoB100

  • ApoE

  • Pancreatic lipase

  • LCAT

Explicación

Pregunta 5 de 20

1

Statins are ineffective in lowering cholesterol levels in individuals with homozygous familial hypercholesterolemia due to which of the following?

Selecciona una de las siguientes respuestas posibles:

  • HMG-CoA reductase is resistant to statins

  • Statins cannot enter the liver cells

  • LDL receptors are nonfunctional

  • Reverse cholesterol transport is inoperative in these patients

  • LCAT is resistant to statin action

Explicación

Pregunta 6 de 20

1

An adult male should have HDL levels equal to or greater than 40 mg/dL. A necessary enzyme contributing to HDL’s protective effect is which of the following?

Selecciona una de las siguientes respuestas posibles:

  • CETP

  • LCAT

  • ACAT

  • AMP-activated protein kinase

  • Protein kinase A

Explicación

Pregunta 7 de 20

1

You have placed a patient on Pravachol pravastatin to reduce her cholesterol. This class of drugs is effective due to a direct inhibition of which of the following?

Selecciona una de las siguientes respuestas posibles:

  • HMG-CoA synthase

  • HMG-CoA reductase

  • Carnitine acyltransferase 1 (CAT-1)

  • Citrate lyase

Explicación

Pregunta 8 de 20

1

A child has been diagnosed with Tay–Sachs disease, in which a particular lipid accumulates within the lysosomes. The component of this lipid which cannot be removed in the lysosome is which of the following?

Selecciona una de las siguientes respuestas posibles:

  • Sphingomyelin

  • Ceramide

  • Fatty acid

  • Glucose

  • N-acetylgalactosamine

Explicación

Pregunta 9 de 20

1

Glutathione is a constituent of

Selecciona una de las siguientes respuestas posibles:

  • Leukotriene A4

  • Leukotriene C4

  • Thromboxane A1

  • None of these

Explicación

Pregunta 10 de 20

1

Cyclo-oxygenase is involved in the synthesis of

Selecciona una de las siguientes respuestas posibles:

  • Prostaglandin

  • Thromboxane

  • Prostaglandin and thromboxane

  • Leukotriene

Explicación

Pregunta 11 de 20

1

Esters of fatty acids with higher alcohols other than glycerol are said to be

Selecciona una de las siguientes respuestas posibles:

  • Waxes

  • Fats

  • None of these

  • Oils

Explicación

Pregunta 12 de 20

1

Carnitine is synthesized from

Selecciona una de las siguientes respuestas posibles:

  • Lysine

  • Serine

  • Choline

  • Arginine

Explicación

Pregunta 13 de 20

1

A patient has been diagnosed with abetalipoproteinemia. A possible deficiency in which of the following vitamins could occur in this patient?

Selecciona una de las siguientes respuestas posibles:

  • Vitamin B1

  • Vitamin B2

  • Niacin

  • Vitamin C

  • Vitamin E

Explicación

Pregunta 14 de 20

1

Which one of the fatty acids listed below can be synthesized by humans?

Selecciona una de las siguientes respuestas posibles:

  • Cis Δ9, 12 C18:2

  • Cis Δ9, 12, 15 C18:3

  • Cis Δ5, 8, 13 C20:3

  • Cis Δ5, 8, 11, 14 C20:4

  • Cis Δ10 C16:1

Explicación

Pregunta 15 de 20

1

You are treating a patient with a fat malabsorption problem, and you suggest that the patient switch his or her diet to one that contains which of the following?

Selecciona una de las siguientes respuestas posibles:

  • Triglycerides with long-chain fatty acids

  • Triglycerides with medium-chain fatty acids

  • Triglycerides with short-chain fatty acids

  • Triglycerides with a mixture of long-chain and short-chain fatty acids

  • Triglycerides with a mixture of long-chain and medium-chain fatty acids

Explicación

Pregunta 16 de 20

1

Treatment of dyslipidemia may involve giving the patient one of these

Selecciona una de las siguientes respuestas posibles:

  • Niacin

  • Lovastatin

  • Vitamin E

  • Mevastatin

Explicación

Pregunta 17 de 20

1

The above prescription works by

Selecciona una de las siguientes respuestas posibles:

  • Lowering serum LDL levels

  • Lowering levels of VLDL and raises levels of HDL

  • Raising LDL levels

  • Increasing bile acids synthesis

  • Inhibiting HMG CoA reductase activity

Explicación

Pregunta 18 de 20

1

The exchange of cholestrol esters for triacylglycerols between HDLs and VLDLs is catalysed by

Selecciona una de las siguientes respuestas posibles:

  • LCAT

  • CETP

  • ACAT

  • Lipoprotein lipase

Explicación

Pregunta 19 de 20

1

Tay-Sachs is to hexosaminidase as Gaucher is to__________

Selecciona una de las siguientes respuestas posibles:

  • Glucocerebrosidase

  • Sphingomyelinase

  • Alpha-galactosidase

  • Arylsulphatase A

Explicación

Pregunta 20 de 20

1

Non-liver and Non-intestine cells get cholesterol from the plasma, rather than synthesizing it de novo from LDL

Selecciona uno de los siguientes:

  • VERDADERO
  • FALSO

Explicación

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