Which of these is not true?
The outer mitochondrial membrane is crossed by facilitated diffusion by cotransport with a proton
Pyruvate is going to be transformed into Acetyl coenzyme A and one molecule of CO2
The oxidative decarboxylation of pyruvate is catalyzed by pyruvate dehydrogenase complex
Pyruvate dehydrogenase complex is constituted by 3 different kind of enzymes and 5 different coenzymes
The pyruvate that is formed in glycolysis will be transferred into mitochondrial matrix
About the enzymes E1, E2 and E3, which of these is true?
1.) Enzyme 1 contains TPP as coenzyme and it is involved in the oxidative decarboxylation of pyruvate
2.) Enzyme 2 contains Lipoamide that is involved in the transfer of one hydroxyethyl group to CoA
3.) Enzyme 3 contains as coenzyme FAD and it is involved in the regeneration of oxidative form of lipoamide
1.) and 3.) are both true
All are true
Pyruvate is going to suffer a oxidative dicarboxylation that is catalyzed by Ez 1, and in this reaction, one molecule of CO2 is going to be released and one hydroxyethyl group is going to be linked to the coenzyme TTP of E1.
In the regulation of PDH, when PDH will be active?
PDH will be active when is not phosphorylated and when levels of NADH and Acetyl CoA are low.
PDH will be active when is phosphorylated and when levels of NADH and Acetyl CoA are low.
PDH will be active when is not phosphorylated and when levels of NADH and Acetyl CoA are high.
PDH will be active when is phosphorylated and when levels of NADH and Acetyl CoA are high.
Any of these
Which of these about the Citric Acid Cycle is not true?
CAC is cycle and it takes place in mitochondria
CAC is one pathway that is used in the metabolism of carbohydrates, amino acids and lipids
It is responsible of the production of 1 third of the total energy (ATP)
It is an amphipathic pathway
There are 3 points of regulation in the cycle
The three reaction regulated in CAC are...?
- Oxaloacetate condense with Acetyl CoA forming Citrate - Alfa-ketoglutarate suffer one oxidative decarboxylation forming Succinyl CoA - Malate is oxydased and one molecule of NADH is formed
- Citrate is transformed to its isomer that is called Isocitrate - Isocitrate suffer one oxidative decarboxylation and it is transformed into alfa-ketoglutarate - Fumarate is transformed into malate
- Oxaloacetate condense with Acetyl CoA forming Citrate - Fumarate is transformed into malate - Malate is oxydased and one molecule of NADH is formed
- Citrate is transformed to its isomer that is called Isocitrate - Isocitrate suffer one oxidative decarboxylation and it is transformed into alfa-ketoglutarate - Succinate is oxydased to fumarate
- Oxaloacetate condense with Acetyl CoA forming Citrate - Isocitrate suffer one oxidative decarboxylation and it is transformed into alfa-ketoglutarate - Alfa-ketoglutarate suffer one oxidative decarboxylation forming Succinyl CoA
For each molecule of AcetylCoA we finally obtain...?
3NADH, 1 FADH2, 1 GTP, 2CO2: 12 ATP
2NADH, 2 FADH2, 1 GTP, 2CO2: 12 ATP
3NADH, 2 FADH2, 1 GTP, 2CO2: 12 ATP
3NADH, 2 FADH2, 2 GTP, 2CO2: 14 ATP
3NADH, 1 FADH2, 1 GTP, 1CO2: 12 ATP
Which are the enzymes that are submitted to CAC regulation?
Citrate synthase, malate dehydrogenase and alfa-ketoglutarate dehydrogenase complex
Citrate synthase, isocitrate dehydrogenase and alfa-ketoglutarate dehydrogenase complex
Citrate synthase, succinate dehydrogenase and alfa-ketoglutarate dehydrogenase complex
Citrate synthase and alfa-ketoglutarate dehydrogenase complex
Any of these is totally true
The inhibitors of the enzymes acting in CAC regulation rare ATP and NADH and the activator is ADP
