Define haemostasis
Production of blood cells
Circulation of blood
Blood clotting/the arrest of bleeding
Which blood components make up haemostatic mechanisms?
Platelets
Vascular epithelium
Fibrinolysis
RBC's
WBC's
Platelets contain granules
Name two traits of platelets
Open canicular structure
No nucleus
Glycoprotein rich surface
Indented membrane
What cells produce platelets (4000 from each cell)?
Megakaryocytes
Myeloblasts
Lymphoblasts
The normal platelet range is 150-400 x10^9/l
Once collagen is exposed, what binds to it?
Van Willibrown Factor
Factor V
Factor III
De Montfort Factor
Platelets bind to _ Factor and release
ADP
Thromborin A2
Thrombulin
ATP
A FBC and film exclude drugs/diseases that cause platelet disorders
What symptoms suggest platelet failure?
Spontaneous/easy bruising
Gastrointestinal Bleed
Epitaxis
A child with a platelet disorder is most likely to have aquired it
How does the Platelet Function Analyser work?
Forces blood through a membrane with a high shear rate and tests clotting time
Forces blood into a medium high in collage and tests clotting time
Forces blood through damaged tubes lined with fibrinogen and tests clotting time
What causes petechiae?
Bleeding under the skin
Spontaneous blood clotting
Spontaneous blood pooling
Bleeding time is rarely done, as it involves damaging the patient further
In an aggregation panel, exposed, concentrated platelets are exposed compared to what?
The last aggregation test taken
A sex matched control
An age and sex matched control
Which of the following hereditary platelet disorders don't have reduced aggregation with Ristocetin?
Van Willebrown disorder
Bernard Soulier Disorder
Glonzmans Thromobasthenia
Only Van Willebrowns disorder doesn't involve missing glycoproteins
Which of the following foods don't effect clotting?
Bananas
Peppers
Onions
Garlic
Name a drug that can reduce blood clotting
Aspirin
Calnexin
Ibruprofen
Myeloproliferative- where excess cells are poduced by the bone marrow
