Immunology Review Questions

1. Which leukocyte is most prevalent in the innate immune response? ❌
2. What cellular component of innate immunity will kill a cell lacking MHCI? ❌
3. What type of cells have TLRs? ❌
4. Which cytokines can cause fever? (hint: the same 3 are the MOST important pro-inflammatory cytokines) ❌
5. What is the hallmark of acute inflammation? ❌
6.what is the hallmark of chronic inflammation? ❌
7. Where is the largest reserve of neutrophils? ❌

1. Is complement involved in innate or adaptive immunity? ❌
2. Where are C3 and C5 produced? ❌
3. What are the 3 ways that C3 can be activated? ❌, ❌, ❌
4. Which complement component is involved in phagocytosis? ❌
5. In a complement fixation assay, if antigen specific antibodies are present what will the test result be? ❌
6. In general, what are the two main responses of the innate immune system once a pathogen gets past anatomical barriers? ❌
7. What are the precursors to tissue macrophages? ❌

1. After a one month bacterial infection, what is the predominant antibody response? ❌
2. During costimulation between an APC and Th cell, what component of the APC binds to CD28? ❌
3. What type of immune response do Th1 cells stimulate? ❌
4. What major cytokines are released during the Th1 response? ❌
5. What type of immune response do Th2 cells stimulate? ❌
6. What major cytokines are released during the Th2 response? ❌
7. Which MHC class does the CD4 TCR bind to? ❌
8. On what type of cells is MHCI located? ❌

1. CD20 is on the surface of what cell type? ❌
2. What are rag1 and rag 2 enzymes involved in? Generation of the ❌
3. What type of antigens are presented on MHC class II? ❌
4. MHC class I interacted with the TCR of which T cell type? ❌
5. What cells express MHC class II? The "professional" APC's --> ❌
6. Which antibody is a pentamer? ❌
7. Which antibody is found in mucous secretions, tears and saliva? ❌
8. What type of immune response is involved in RA? ❌

1. Where do T cells mature? ❌
2. Which complement component is on the surface of microbial cells? ❌
3. What initiates the lectin binding pathway in complement? ❌
4. What antibody is produced in the GALT? ❌
5. What antibody is involved in the allergic response? ❌
6. What component of the T cell is destroyed by HIV? ❌
7. A person with anti-A serum is what blood type? ❌

1. Molecular mimicry from which organism causes myocarditis in acute rheumatic fever? ❌
2. What type of hypersensitivity reaction is that (referring to question 1)? ❌
3. Soluble immune complexes are involved in which hypersensitivity? ❌
4. What type of hypersensitivity reaction is acute transplant rejection? ❌
5. Give examples of type III hypersensitivities. ❌ (immune complexes deposit in kidneys and cause glomerulonephritis), ❌ (immune complexes deposit into joints)
6. What is the characteristic appearance of SLE? ❌ rash (❌)
7. Type IV hypersensitivity reactions involve what cell type? ❌ (no antibodies are involved)
8. What do mast cells release during the early phase response in type I hypersensitivity? ❌

1. Antibodies against epidermal cadherin resulting in blistering of the skin is characteristic of what? ❌ ❌ hypersensitivity)
2. What type of cells destroy tumor cells? ❌
3. Give an example of an ❌. Transplant btw individuals that are not identical twins
4. Which immune responses are involved in chronic transplant rejection? ❌
5. What is the most effective type of vaccine and why? ❌ because it is able to induce ❌
6. What is are routes of administration for vaccines? ❌, ❌, ❌

1. What are anti-inflammatory agents that suppress the immune system? ❌
2. What type of cancer cell is used in the construction of mabs? ❌
3. Give an example of an anti-TNF alpha mab. ❌
4. Ipilimumab is a mab against which antigen that is a negative T cell regulator? ❌