K (KOPr)

d (DOPr)

M (MOPr)

Analgesia

Physical dependence

Which G proteins are opiod receptors coupled to?

Physical dependence

Psychological dependence

Euphoria and drowsiness

Respiratory depression

Nausea

Miosis

Morphine

Heroin

Codeine

Pentacozine

Tramadol

Naloxone

Carbamazepine

Gabapentine

Amytryptyline

Problems with opioids as analgesics

Therapeutic uses of opioids

Consequences of MR +

Sites of action

Supraspinal sites of action

Review