Cancer Chemotherapy

What is the scientific name for cancer?

What is the word used for a cancerous growth?

Carcinomas derive from

What type of tumour derives from connective tissue?

What type of tumour derives from thin layers of tissue surrounding internal organs?

What type of tumour derives from glial cells in the brain?

derive from germ cells (which are non- cells)

What does leukemia derive from?

The proportion of tumour cells dividing and cycling is known as the

Name three folic acid antagonists.
1 -
2 -
3 -

Name four pyrimidine analogues.
1 -
2 -
3 -
4 -

Name five purine analogues.
1 -
2 -
3 -
4 -
5 -

Methotrexate works by attacking/inhibiting reductase. This prevents being converted into .

Name two main nitrogen mustard based alkylating agents.
1 -
2 -

Alkylating agents, such as , work by between nitrogenous bases. This produces a structure which is hard to break meaning DNA is not longer able to .

Cisplatin and carboplatin are examples of which anticancer type drugs?

Name two platinating agents.
1 -
2 -

Which main element do platinating agents contain?

In conditions, the group of platinating agents is replaced with . The nitrogen on the base can displace water and binds tightly to the drug.

Antitumor antibiotics and derived from species.

Name six main groups/drugs of antibiotics used in cancer chemotherapy (in alphabetical order).
1 -
2 -
3 -
4 -
5 -
6 -

The main anticancer anthracycline antibiotic is .

Which enzyme does doxorubicin inhibit?

What is the main adverse effect of anthracyclines?

Dactinomycin works mainly by with DNA at the complex, which prevents action.

Bleomycin works by with ions (mainly ), which produces that DNA. Oxygen is required for this to occur.

Mitomycin C is a . It is enzymatically activated to produce an metabolite.

Procarbazine is a which breaks down to in the body. This reaction produces which causes damage to . It interferes with DNA and RNA .

is used for the treatment of chronic myelogenous leukaemia.

Hydroxycarbamide works by inhibiting . This enzyme is responsible for catalysing DNA from RNA strands.

What is the main side effect of hydroxycarbamide?

Name four plant derived cancer therapy agents.
1. C
2. E
3. T
4. V a

Vinca alkaloids work by binding to . This prevents formation in mitosis. The disruption of stops mitosis in . Vinca alkaloids affect all dividing cell types.

The brand name for vincristine is

Name two taxane drugs.
1.
2.

Taxanes work by stabilising preventing .

Name two camptothecins.
1. t
2. i

Name six anthracyclines (other than doxorubicin)
1 - a
2 - a
3 - d
4 - e
5 - i
6 - m