Which of the following mechanisms best describes the mode of action of the sulphonylurea class of drugs?
Stimulates insulin synthesis.
Enhances insulin binding to the beta cell insulin receptor.
Stimulates insulin secretion.
Stimulates conversion of proinsulin to insulin and C-peptide.
Stimulates beta cell proliferation.
The deterioration in glycaemic control over time seen in patients with type 2 (non-insulin-dependent) diabetes mellitus is primarily due to:
medication non-compliance.
increasing insulin resistance.
increasing obesity.
decreasing insulin secretion.
reduced energy expenditure
Which of the following drugs used in diabetes treatment is most likely to cause hypoglycemia?
Repaglinide.
Metformin.
Acarbose.
Rosiglitazone.
Orlistat.
In a patient with Type 2 diabetes which of the following co-existing clinical situations is the strongest contraindication to the use of a thiazolidinedione drug?
Fatty liver disease.
Peripheral vascular disease.
Severe congestive cardiac failure.
Proliferative diabetic retinopathy.
Serum creatinine 200μmol/L.
In patients with Type 1 Diabetes, the greatest benefit in using a long acting insulin analogue is in reducing which of the following
Diabetic Retinopathy
Nocturnal hypoglycemia
insulin hypersensitivity
preprandial hyperglycemia
microalbuminuria
Glucagon-like peptide–1, secreted postprandially by the L-cells in the intestine, increases which of the following?
Gastric emptying.
Body weight.
Insulin secretion.
Hepatic glucose output.
Insulin sensitivity (sulphonylurea, thiazolidinediones)
