Pathology - Cell Injury, Cell Death and Adaptations

Cellular response to stress and noxious stimuli

Adaptations to stress

Hypertrophy

Hyperplasia

Atrophy

Metaplasia

Causes of cell injury

Reversible cellular injury

Two types of reversible cellular injury

Cell death

Apoptosis vs necrosis

Apoptosis - physiological causes

Apoptosis - pathological causes

Apoptosis - mechanisms

Apoptosis - intrinsic (mitochondrial) pathway

Apoptosis - extrinsic (death receptor) pathway

Necrosis - morphology

Necrosis - mechanisms

Necrosis - depletion of ATP

Necrosis - mitochondrial damage

Necrosis - oxidative stress