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When DNA replicates, each strand of the original DNA molecule is used as a template for the synthesis of a second, complementary strand. To start DNA synthesis, DNA helicase moves along the template strand to "unzip" it. The top strand is called the leading
lagging ( leading, lagging ) strand and starts with 5'
3' ( 5', 3' ) and ends with 3'. In contrast, the bottom strand, or the lagging
leading ( lagging, leading ) strand, starts with 3'
5' ( 3', 5' ) and ends with 5'. The strands are unwound/replicated in opposite
similar ( opposite, similar ) directions.