Protein Secretion & The SecY Pathway

SecY

TAT (Twin Argernine System)

Secretion Systems (Types I-IV & VI)

Type V Autotransporter

SecY- Protein Sorting/Targeting

SecY- SecB

SecY- SRP

SecY- Translocation Protein Channel

SecY-SecA

SecY- Release

SecY-Channel

1) Sec B dimer binds the protein and...

2) The 'plug' keeps SecY closed until...

3) ATP hydrolysis causes....

SecB Dependent- Destination

SecB Dependent- Is the protein folded

SecB Dependent- Channel Target

SRP Dependent- Destination

SRP Dependent- Ribosome binding

SRP Dependent- Channel Target

SRP Dependent- Folded

Sec Y Signal Peptide- Length

Sec Y Signal Peptide- N Region

Sec Y Signal Peptide- H Region

Sec Y Signal Peptide- C Region