Where is the carboxylase termunus regulatory region found?
Inside the cell
Outside the cell
In the membrane
How are the alpha and beta chains connected?
Electrostatic interactions
Disulphide bonds
What is the active site of insulin receptor?
Tyrosine kinase
Skeletons
Toast
The active site of Insulin receptors work exactly the same as other tyrosine kinases
What does IRS stand for?
Inland Revenue Service
Insulin Receptor Substrate
There are six different versions of the IRS
How does the IRS bind to the Insulin receptor?
PTB- Phosphotyrosine Binding Site
PSB- Phosphoserine Binding Sire
The Insulin Receptor response pathway is the same as the MAPK pathway until MAPK activates
Insulin Sensitive Protein Kinase (ISPK)
Insulin Responsive Protein Kinase (IRPK)
Insulin Dependent Protein Kinase (IDPK)
ISPK activates Protein Phosphatase 1, which reverses te effect of adrenaline/glucagon through phoshphorylation
IRS can also work through the PI3K pathway, leading to the conversion of PI2 to what?
PI
PI3
PI-2,5-BP
The action of the PI3K pathway causes the activation of PKB
The P of PKB causes the P and deactivation of what?
Glycogen Synthase Kinase-3
Glycogen Phosphorylase
Why does PKB increase phosphodiesterase activity?
Reverses phosphorylation done by glucaon
Lowers cAMP
