E2. _Bioc_Lec1_ CarbMetaAndGlyc

Pregunta 1 de 50

1

Selecciona la opción correcta de los menús desplegables para completar el texto.

Hexose are ( 6, 5, 4, 7 ) Carbon ( Carbohydrates, Proteins, Nucleic Acids, Lipids ) and are typically used for energy metabolism. Examples include ( Glucose, Fructose, Mannose, and Galactos, RIbose, Deoxyribose, NADH, and Galactos )e.

Pentose are ( 5, 4, 6, 7 ) carbon carbohydrates and are typically used in ( larger molecules, energy metabolism, plants, not humans ). Examples include ( Ribose, Deoxyribose, and NADH, Glucose, Fructose, Mannose,and Galactose ).

The difference in deoxyribose and ribose is with the ( H/OH, OH/H, N/lackthereof, Lackthereof/N, COO/CO, CO/COO ) group at the ( 2', 1', 3', 4', 5', 6' ) location. ( DNA, RNA ) is more stable than ( RNA, DNA ).

Stereoisomers- ( Alpha, Beta, Gamma, Delta ) is when the ( 1', 2', 3', 4' ) OH group is ( below, above, on the same plane as ) the ring, while ( beta, alpha, gamma, delta ) is when the ( 1, 2, 3, 4 )' OH group is ( above, below, in the same plane as ) the ring. This difference has a ( profound, minimal, undocumented/unexplored ) impact on its biological uses and enzyme binding.

( D and L, A and B, X and Y, G and M, Q and R, R and L, C and D ) sugars are enantiomers, which means they are ( mirror, identical, completely different, 90 degrees rotated ) images of each other. Most mammal sugars are in the ( D, L ) configuration, while ( L, D ) sugars are typically found in plants and microorganisms.

Explicación

Pregunta 2 de 50

1

Polysaccharides can be used for _____________ in plants and animals

Selecciona una de las siguientes respuestas posibles:

storage
structure
all of the above
none of the above

Explicación

Pregunta 3 de 50

1

Disaccharides are used for

Selecciona una de las siguientes respuestas posibles:

Storage
Structure
All of the above
None of the above

Explicación

Pregunta 4 de 50

1

Beta Glucose linkage is typically seen in

Selecciona una de las siguientes respuestas posibles:

Glycogen
Starch
Chitin
Cellulose

Explicación

Pregunta 5 de 50

1

Chitin uses ____ as its main building block

Selecciona una de las siguientes respuestas posibles:

Alpha linked glucose
Beta linked glucose
gamma linked glucose
N acetyl glucosamine (a linked)
N acetyl Glucosamine (beta linked)
N acetyl Glucosamine (gamma linked)

Explicación

Pregunta 6 de 50

1

Glycogen uses glucose in what kind of linkage?

Selecciona una de las siguientes respuestas posibles:

Alpha
Beta
Gamma
Delta
Reserve
CIS
Trans
Mirrored
Trick question, they arent linked

Explicación

Pregunta 7 de 50

1

Disaccharides can enter the metabolic pathways with no prior modification or cleveage

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 8 de 50

1

Glycolysis is the breakdown of glucose into Acetyl-CoA

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 9 de 50

1

Rellena los espacios en blanco para completar el texto.

is converted into compounds, coupled with production.

Glycolysis occurs in cells of the body and the reaction occurs exclusively in the .

Explicación

Pregunta 10 de 50

1

Glycolysis requires Oxygen to procede

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 11 de 50

1

Rellena los espacios en blanco para completar el texto.

is a sequence of reactions that convert to . This requires an investment of but produces a net of . There is one step that converts NAD to NAD.

Explicación

Pregunta 12 de 50

1

Glycolysis is a unique reaction chain that is not linked to other biochemical pathways

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 13 de 50

1

glucose (6-C; Six Carbon) is broken into:

Selecciona una de las siguientes respuestas posibles:

2 3-C molecules
3 2-Cmolecules
1 4-C molecule and 1 2-Cmolecule
none of the above
1 5-C molecule and 1 CO2 (1-C) molecule

Explicación

Pregunta 14 de 50

1

ALL of the enzymes used in the glycolysis pathway are unique to the forward reaction of glycolysis to pyruvate

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 15 de 50

1

Phosofructokinase is NOT a rate limiting setp

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 16 de 50

1

The Hexokinase reaction precedes the Glucokinase reaction

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 17 de 50

1

GLUCOKINASE is ONLY found in the LIVER and PANCREAS
HEXOKINASE is found in ALL OTHER CELLS/TISSUES.

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 18 de 50

1

Outside of location, the major difference between Hexokinase and Glucokinase is the fact Glucokinase has a lower affinity for Glucose.

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 19 de 50

1

Hexokinase catalyzes the reaction of Glucose to Glucose 1 Phosphate

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 20 de 50

1

Glucose gets converted to fructose as a part of glycolysis.

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 21 de 50

1

Phospofructokinase catalyzes the reaction of Fructose 6 phosphate to Fructose 1,6 bisphosphate

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 22 de 50

1

Rellena los espacios en blanco para completar el texto.

Aldose catalyzes the reaction of into

Explicación

Pregunta 23 de 50

1

Aldose cleave Glucose 1,6 bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3 phosphate

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 24 de 50

1

Dihydroxyacetone phosphate gets directly converted to 1,3 bisphosphoglycerate

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 25 de 50

1

NADH is produced by which enzyme, which also requires Mg as a cofactor

Selecciona una de las siguientes respuestas posibles:

Hexokinase
Phospohexokinase Isomerase
Aldoase
glyceraldehyde 3 phosphate dehydrogenase

Explicación

Pregunta 26 de 50

1

Which of the following enzymes (or their associated rxns) require Mg?

Selecciona una o más de las siguientes respuestas posibles:

Hexokinase
Phosphoglucose isomerase
phosphofructosekinase
aldoase
Triosephosphate isomerase
glyceraldehyde 3 phosphate dehydrogenase
phosphoglycerate kinase
phosphoglycerate mutase
Enolase
Pyruvate Kinase

Explicación

Pregunta 27 de 50

1

In Anaerobic conditions NADH is used with pyruvate to generate lactate

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 28 de 50

1

It is better to rest completely when fatigued (high lactate levels) from exercise

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 29 de 50

1

Rellena el espacio en blanco para completar el texto.

1,3 bisphosphoglycerate to 3 phosphoglycerate produces ATP via

Explicación

Pregunta 30 de 50

1

The major regulatory points are which of the following enzymes

Selecciona una o más de las siguientes respuestas posibles:

phosphofructosekinase
hexokinase (glucokinase)
pyruvate kinase
phosphoglucose isomerase
aldolase
Triosephosphate isomerase

Explicación

Pregunta 31 de 50

1

The major regulatory points are all reversible reactions using the same enzyme.

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 32 de 50

1

Pyruvate kinase catalyze the forward and reverse reaction from phosphoenolpyruvate to pyruvate, and also generates one atp molecule

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 33 de 50

1

Which enzyme is the RATE LIMITING STEP

Selecciona una de las siguientes respuestas posibles:

Phosphofructokinase
Hexokinase/Glucokinase
Pyruvate Kinase

Explicación

Pregunta 34 de 50

1

Phosphofructokinase responds to

Selecciona una o más de las siguientes respuestas posibles:

energy state (ATP as a positive regulator)
H+ concentration (lactate is a positive regulator)
Citrate s a positive regulator
Citrate as a negative regulator
energy state (ATP as a negative regulator)
H+ concentration (lactate is a negative regulator)
Insulin to glucagon ratio in blood (Fructose 2 6bisphosphate is a positive regulator)
Insulin to glucagon ratio in blood (Fructose 2 6bisphosphate is a negative regulator)

Explicación

Pregunta 35 de 50

1

What is the effect of F-2,6-BP on phosphofructokinase activity on the graph [Velocity (Y) vs concentration of F6P (x)]

Selecciona una de las siguientes respuestas posibles:

Shifts Graph Left, It is an activator
Shifts Graph Right, It is an activator
Shifts Graph Left, It is an inhibitor
Shifts Graph Right, It is an inhibitor

Explicación

Pregunta 36 de 50

1

Fructose 2, 6 Bis Phosphate is produced by Glycolysis

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 37 de 50

1

Pyruvate Kinase is phosphorylated to make it more active

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 38 de 50

1

Phosphorlyation of PK is downregulated by low blood glucose levels.

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 39 de 50

1

Rellena los espacios en blanco para completar el texto.

Pyruvate is upregulated by and downregulated by and

Explicación

Pregunta 40 de 50

1

Rellena los espacios en blanco para completar el texto.

Summary Slide!

is the conversion of to with and NAD production.

Glycolysis is critical for brain and erythrocyte and muscles.

, , and catalyze key steps in glycolysis.

catalyzed the and is by levels of .

is a site of secondary . it undergoes to make it .

Under conditions NAD is regenerated by conversion of to .

Explicación

Pregunta 41 de 50

1

Rellena los espacios en blanco para completar el texto.

According to the video from slide 16, Glycolysis can be thought of in 3 different phases.

1) Energy (steps to )
2). Glucose (steps to )
3). Energy (steps to )

Explicación

Pregunta 42 de 50

1

Rellena los espacios en blanco para completar el texto.

sensing is conducted by the . They require glucose via the transport protein, and its via the pathway.

Explicación

Pregunta 43 de 50

1

The pancreas uses hexokinase not glucokinase

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 44 de 50

1

To sense the levels of glucose in the blood, Pancreatic Beta cells uptake glucose via GLUT2, where it is then processed into ATP (VIa glycolysis, the TCA and Phos Ox). The ATP levels rise and open and K channel which allows an influx of K, triggering membrane depolarization. This then triggers a Voltage dependent Calcium channel to close allowing an influx of Ca into the cell which triggers the release (exocytosis) of insulin filled vesicles.

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 45 de 50

1

A defect in the gene coding for which enzyme of glycolysis has been linked to early onset diabetes (T-2)

Selecciona una de las siguientes respuestas posibles:

Hexokinase (II)
Glucokinase
Phospofructokinase
Aldolase
Pyruvate Kinase
Phosphoglycerate kinase

Explicación

Pregunta 46 de 50

1

Just seeing food can trigger the release of insulin via the parasympathetic nervous system

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 47 de 50

1

Which cycle converts converts lactate back into glucose via glucoenogensis?

Selecciona una de las siguientes respuestas posibles:

Cori Cycle
Krebs Cycle
Alanine Cycle
Kori Cycle
Phenlyalanine Cycle
Calvin Cycle

Explicación

Pregunta 48 de 50

1

The alanine cycle recyles alanine produced by glucose metabolism to pyruvate and alanine. This cycle occurs exclusively in muscle cells and converts alanine back into glucose via pyruvate and gluconeogensis.

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 49 de 50

1

DISEASE QUESTION PLACEHOLDER

Selecciona una de las siguientes respuestas posibles:

This one
not this one

Explicación

Pregunta 50 de 50

1

Label the substrates/products, enzymes, and net reaction. Use Tags labeled with the prefix "R: " for the net reaction box in the bottom right. If the molecule is used multiple times, is the lowest suffix (ie_1) first.

{"1.95877_9.47368":[{"id":11204392,"answer":"Pyruvate","x":1.95877,"y":9.47368}],"11.6775_12.8521":[{"id":11204391,"answer":"Pyruvate Kinase","x":11.6775,"y":12.8521}],"7.47783_28.2456":[{"id":11204393,"answer":"Phosphoenolpyruvate","x":7.47783,"y":28.2456}],"22.8523_21.0526":[{"id":11204394,"answer":"Enolase","x":22.8523,"y":21.0526}],"32.5764_16.1404":[{"id":11204405,"answer":"Glucose","x":32.5764,"y":16.1404}],"20.7498_32.6316":[{"id":11204395,"answer":"2phosphoglycerate","x":20.7498,"y":32.6316}],"43.2203_9.12281":[{"id":11204406,"answer":"Hexokinase/Glucokinase","x":43.2203,"y":9.12281}],"37.307_25.0877":[{"id":11204396,"answer":"Twice","x":37.307,"y":25.0877}],"38.8839_33.1579":[{"id":11204397,"answer":"Phosphoglycerate mutase","x":38.8839,"y":33.1579}],"51.7617_17.7193":[{"id":11204407,"answer":"Glucose 6 phosphate","x":51.7617,"y":17.7193}],"39.4095_44.5614":[{"id":11204398,"answer":"3 phosphoglycerate","x":39.4095,"y":44.5614}],"61.8799_12.1053":[{"id":11204408,"answer":"phosphoglucose isomerase","x":61.8799,"y":12.1053}],"61.0915_23.8596":[{"id":11204409,"answer":"Fructose 6 phosphate","x":61.0915,"y":23.8596}],"55.5724_42.9825":[{"id":11204399,"answer":"Phosphoglycerate Kinase","x":55.5724,"y":42.9825}],"52.4187_58.0702":[{"id":11204400,"answer":"1,3 Bisphosphoglycerate","x":52.4187,"y":58.0702}],"73.8379_35.7895":[{"id":11204413,"answer":"fructose 1,6 Bisphosphate","x":73.8379,"y":35.7895}],"67.1362_47.7193":[{"id":11204401,"answer":"Glyceraldehyde 3 phosphate dehydrogenase","x":67.1362,"y":47.7193}],"81.328_23.1579":[{"id":11204411,"answer":"Phosphofructose kinase","x":81.328,"y":23.1579}],"42.5632_73.1579":[{"id":11204417,"answer":"R: Glucose","x":42.5632,"y":73.1579}],"74.4949_44.2105":[{"id":11204402,"answer":"Glyceraldehyde 3 phosphate","x":74.4949,"y":44.2105}],"41.3806_83.8596":[{"id":11204420,"answer":"R: ATP_1","x":41.3806,"y":83.8596}],"60.9601_72.6316":[{"id":11204418,"answer":"R: Pyruvate","x":60.9601,"y":72.6316}],"83.5619_51.0526":[{"id":11204404,"answer":"triosephosphate isomerase","x":83.5619,"y":51.0526}],"92.1033_42.807":[{"id":11204415,"answer":"Aldolase (FructoseBisphosphateAldolase)","x":92.1033,"y":42.807}],"58.7262_84.7368":[{"id":11204419,"answer":"R: ATP_2","x":58.7262,"y":84.7368}],"42.4318_96.1404":[{"id":11204422,"answer":"NAD+","x":42.4318,"y":96.1404}],"86.4529_60.1754":[{"id":11204403,"answer":"Dihydroxyacetone phosphate","x":86.4529,"y":60.1754}],"49.5278_95.4386":[{"id":11204423,"answer":"E-","x":49.5278,"y":95.4386}],"73.3123_95.2632":[{"id":11204424,"answer":"NADH","x":73.3123,"y":95.2632}],"86.4529_84.7368":[{"id":11204421,"answer":"R: ATP_3","x":86.4529,"y":84.7368}]}

Arrastra la opción correcta a cada uno de los puntos naranjas

Pyruvate Kinase

Pyruvate

Phosphoenolpyruvate

Enolase

2phosphoglycerate

Twice

Phosphoglycerate mutase

3 phosphoglycerate

Phosphoglycerate Kinase

1,3 Bisphosphoglycerate

Glyceraldehyde 3 phosphate dehydrogenase

Glyceraldehyde 3 phosphate

Dihydroxyacetone phosphate

triosephosphate isomerase

Glucose

Hexokinase/Glucokinase

Glucose 6 phosphate

phosphoglucose isomerase

Fructose 6 phosphate

Phosphofructose kinase

fructose 1,6 Bisphosphate

Aldolase (FructoseBisphosphateAldolase)

R: Glucose

R: Pyruvate

R: ATP_2

R: ATP_1

R: ATP_3

NAD+

E-

NADH

	Creado por Sahil Bharwani hace alrededor de 8 años

Biochem E2L1, GLYCOLYSIS. 49 is a palceholder till slides are released/

E2. _Bioc_Lec1_ CarbMetaAndGlyc

Pregunta 1 de 50

Selecciona la opción correcta de los menús desplegables para completar el texto.

Explicación

Pregunta 2 de 50

Polysaccharides can be used for _____________ in plants and animals

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 3 de 50

Disaccharides are used for

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 4 de 50

Beta Glucose linkage is typically seen in

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 5 de 50

Chitin uses ____ as its main building block

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 6 de 50

Glycogen uses glucose in what kind of linkage?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 7 de 50

Disaccharides can enter the metabolic pathways with no prior modification or cleveage

Selecciona uno de los siguientes:

Explicación

Pregunta 8 de 50

Glycolysis is the breakdown of glucose into Acetyl-CoA

Selecciona uno de los siguientes:

Explicación

Pregunta 9 de 50

Rellena los espacios en blanco para completar el texto.

is converted into compounds, coupled with production. Glycolysis occurs in cells of the body and the reaction occurs exclusively in the .

Explicación

Pregunta 10 de 50

Glycolysis requires Oxygen to procede

Selecciona uno de los siguientes:

Explicación

Pregunta 11 de 50

Rellena los espacios en blanco para completar el texto.

is a sequence of reactions that convert to . This requires an investment of but produces a net of . There is one step that converts NAD to NAD.

Explicación

Pregunta 12 de 50

Glycolysis is a unique reaction chain that is not linked to other biochemical pathways

Selecciona uno de los siguientes:

Explicación

Pregunta 13 de 50

glucose (6-C; Six Carbon) is broken into:

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 14 de 50

ALL of the enzymes used in the glycolysis pathway are unique to the forward reaction of glycolysis to pyruvate

Selecciona uno de los siguientes:

Explicación

Pregunta 15 de 50

Phosofructokinase is NOT a rate limiting setp

Selecciona uno de los siguientes:

Explicación

Pregunta 16 de 50

The Hexokinase reaction precedes the Glucokinase reaction

Selecciona uno de los siguientes:

Explicación

Pregunta 17 de 50

GLUCOKINASE is ONLY found in the LIVER and PANCREAS HEXOKINASE is found in ALL OTHER CELLS/TISSUES.

Selecciona uno de los siguientes:

Explicación

Pregunta 18 de 50

Outside of location, the major difference between Hexokinase and Glucokinase is the fact Glucokinase has a lower affinity for Glucose.

Selecciona uno de los siguientes:

Explicación

Pregunta 19 de 50

Hexokinase catalyzes the reaction of Glucose to Glucose 1 Phosphate

Selecciona uno de los siguientes:

Explicación

Pregunta 20 de 50

Glucose gets converted to fructose as a part of glycolysis.

Selecciona uno de los siguientes:

is converted into compounds, coupled with production.

Glycolysis occurs in cells of the body and the reaction occurs exclusively in the .

GLUCOKINASE is ONLY found in the LIVER and PANCREAS
HEXOKINASE is found in ALL OTHER CELLS/TISSUES.