Figure 10–8. Signal transduction mechanisms in early LTP. The trigger for the induction of LTP is Ca2 permeating through the NMDA receptor. This is amplified by Ca2 release from Ca2/IP3- sensitive stores. The amplified Ca2 signal together with other activators of protein kinases (zigzag arrows) then leads to the phosphorylation of substrate proteins, including AMPA and NMDA receptors, and the insertion of AMPA receptors into the postsynaptic membrane (not shown). These post-translational processes contribute to E-LTP. Protein synthesis-dependent mechanisms at the synapse and by signals passing to the nucleus are responsible for L-LTP. Putative retrograde messengers, Nitric oxide (NO) and arachidonic acid (AA), that may stimulate presynaptic changes are also indicated. (Source: After Bliss and Collingridge, 1993.)

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Synaptic plasticity Apunte sobre Expression of LTP, creado por Cher Bachar el 05/05/2013.