There is a positive negative inverse trigonometric( positive, negative, inverse, trigonometric ) correlation between substrate concentration and initial rate of reaction. However, past a point, the graph plateaus goes the opposite way becomes inverted decreases( plateaus, goes the opposite way, becomes inverted, decreases ). This is because of a limiting factor extreme pH extreme temperature denatured enzymes( a limiting factor, extreme pH, extreme temperature, denatured enzymes ), which is the enzyme concentration substrate concentration enzyme's optimum temperature space available in the cell( enzyme concentration, substrate concentration, enzyme's optimum temperature, space available in the cell ). At this point and beyond, the enzymes are said to be saturated denatured acidic dissolved( saturated, denatured, acidic, dissolved ).

Inhibitors that block acidify expose signal( block, acidify, expose, signal ) the active site tertiary structure synthesis degradation( active site, tertiary structure, synthesis, degradation ) of enzymes are competitive non-competitive( competitive, non-competitive ), whereas inhibitors that change block expose precipitate( change, block, expose, precipitate ) the shape primary structure kinetic energy( shape, primary structure, kinetic energy ) of enzymes are non-competitive competitive( non-competitive, competitive ).

Potassium cyanide Potassium hydrochloride Hydrogen peroxide( Potassium cyanide, Potassium hydrochloride, Hydrogen peroxide ) is an inhibitor that is also a metabolic poison. In the body, it forms hydrogen cyanide potassium ions potassium hydrogen carbonate( hydrogen cyanide, potassium ions, potassium hydrogen carbonate ). The cyanide hydrogen potassium( cyanide, hydrogen, potassium ) ions bind irreversibly weakly reversibly( irreversibly, weakly, reversibly ) to mitochondria DNA the cytoskeleton ATP synthase( mitochondria, DNA, the cytoskeleton, ATP synthase ) and prevent normal aerobic respiration protein synthesis DNA replication DNA reparation( aerobic respiration, protein synthesis, DNA replication, DNA reparation ).
Snake venom contains acetylcholinesterase acetylcholine cholinesterase GABAesterase( acetylcholinesterase, acetylcholine, cholinesterase, GABAesterase ), which prevents the breakdown of acetylcholine acetylcholinesterase glycogen ATP( acetylcholine, acetylcholinesterase, glycogen, ATP ), thereby preventing muscle relaxation.
Various therapeutic drugs are available that work by inhibiting enzymes such as ACE blood pressure angiotensin pepsin( ACE, blood pressure, angiotensin, pepsin ), proteases proteins starch iodine( proteases, proteins, starch, iodine ), and ATPase ATP synthase potassium cyanide acetylcholine( ATPase, ATP synthase, potassium cyanide, acetylcholine ).