Pharmaceutics I

Pregunta 1 de 25

1

By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a
finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the
minimum number of phases present in a dispersed system?

Selecciona una de las siguientes respuestas posibles:

1
2
3

Explicación

Pregunta 2 de 25

1

The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of
the dispersed phase?

Selecciona una de las siguientes respuestas posibles:

Solid state
Particle size
Molecular weight
Chemical structure

Explicación

Pregunta 3 de 25

1

Why might a dispersed phase containing drug be formulated in a dispersion medium in which it
was insoluble?

Selecciona una de las siguientes respuestas posibles:

To increase the solubility
To mask bitter tastes
To increase the viscosity
To decrease the viscosity
None of the above

Explicación

Pregunta 4 de 25

1

Given the equation for Stoke’s law of settling below, by how much you have to increase the
viscosity to offset a particle size increase of a factor of two?

Selecciona una de las siguientes respuestas posibles:

Factor of 1/2
Factor of 2
Factor of 4

Explicación

Pregunta 5 de 25

1

Given a suspension with a fixed particle size distribution, what would be true if each powder
particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of
dispersion medium)?

Selecciona una de las siguientes respuestas posibles:

The viscosity would be infinite
The settling rate will be very high
The settling rate would be zero
The particle size would approach colloidal dimensions

Explicación

Pregunta 6 de 25

1

The primary mechanism of altering dispersion medium properties is modification of:

Selecciona una de las siguientes respuestas posibles:

Density
Viscosity
Dielectric constant

Explicación

Pregunta 7 de 25

1

Which of the following characteristics is NOT desirable in the case of suspension dosage forms?

Selecciona una de las siguientes respuestas posibles:

Flocculation with formulation of loosely bound aggregates
Flocculation with formulation of strongly bound aggregates
Formation of loose sediment

Explicación

Pregunta 8 de 25

1

An advantage of a shear thinning formulation includes:

Selecciona una de las siguientes respuestas posibles:

Ease of mixing with relatively mild shaking of the container
Lower viscosity on standing to prevent settling
Caking of needle shaped particles

Explicación

Pregunta 9 de 25

1

Under what conditions would you compound a suspension using benzyl alcohol or propylene
glycol for preemies?

Selecciona una de las siguientes respuestas posibles:

Only for acute usage
Only for antibiotics
Never

Explicación

Pregunta 10 de 25

1

You are asked to compound a suspension of a drug normally dispensed as a solid dosage form.
Why is it prudent to determine if a liquid dosage form is also commercially available?

Selecciona una de las siguientes respuestas posibles:

You can save the effort and advise the patient they must wait until you can order the
commercial dosage form
If a commercial liquid dosage form isn’t available, it may indicate a potential chemical
stability problem
If a commercial liquid dosage form isn’t available, it may indicate a potential physical
stability problem
Both B and C

Explicación

Pregunta 11 de 25

1

Select the choices that correctly fill the blanks in the following statement: the three minimum
requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) 2) 3).

Selecciona una de las siguientes respuestas posibles:

1) Components forming at least 2 phases, 2) a component to stabilize the interface between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
1) At least one solid component 2) amphiphilic surfactant molecules, 3) adjustment to physiologic pH
1) Component forming liquid crystalline phases, 2) a component to overcome the “double layer between the internal and external (continuous) phase, 3) sufficient energy input to break up each phase into droplets.
All of the above

Explicación

Pregunta 12 de 25

1

Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically
unstable?

Selecciona una de las siguientes respuestas posibles:

Dispersed phase tends to form aggregates of globules on standing
Aggregates of the dispersed phase may be re-dispersed by shaking
Large globules or aggregates of globules rise to the top or fall to the bottom of container forming a concentrated layer of dispersed phase
All or part of the liquid in the dispersed phase separates to form a distinct layer

Explicación

Pregunta 13 de 25

1

Patients should virtually never be instructed to store an emulsion dosage form:

Selecciona una de las siguientes respuestas posibles:

In the refrigerator
At room temperature
In the freezer

Explicación

Pregunta 14 de 25

1

The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase
in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of
Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):

Selecciona una de las siguientes respuestas posibles:

72 and 28% respectively
28 and 72% respectively
None of the above

Explicación

Pregunta 15 de 25

1

A magma is a:

Selecciona una de las siguientes respuestas posibles:

Two phase gel in which the gel mass does not consists of floccules of small distinct particles
One phase gel in which the gel mass consists of floccules of small distinct particles
Two phase gel in which the gel mass consist of floccules of small distinct particles

Explicación

Pregunta 16 de 25

1

In a colloidal dispersion the particle size is:

Selecciona una de las siguientes respuestas posibles:

Much smaller than typical molecule dimensions
Much larger than typical molecule dimensions
The same or smaller than typical molecule dimensions

Explicación

Pregunta 17 de 25

1

Which of following is FALSE in case of gel formulation exhibiting syneresis?

Selecciona una de las siguientes respuestas posibles:

A measurable increase in volume of Gel
A non-measurable change in the volume of Gel
A measureable decrease in volume of Gel
A and B
B and C

Explicación

Pregunta 18 de 25

1

What is a major function of glycerin in the carboxymethylcellulose based gel formulations?

Selecciona una de las siguientes respuestas posibles:

To prevent drying of Gel
Sweetner
Antioxidant

Explicación

Pregunta 19 de 25

1

Which of following if true of aerosol used to provide an airborne mist?

Selecciona una de las siguientes respuestas posibles:

Particle size >50μm
Particle size <50 μm
Particle size <1μm
None of above

Explicación

Pregunta 20 de 25

1

A properly prepared pharmaceutical suspension should settle slowly and should readily re
dispersed upon gentle shaking on the container

Selecciona uno de los siguientes:

VERDADERO
FALSO

Explicación

Pregunta 21 de 25

1

Which of the following excipients should not be used in the formulation of a Carboxymethylcellulose-based gel?

Selecciona una de las siguientes respuestas posibles:

Preservative
Glycerin
Alcohol
None of the above

Explicación

Pregunta 22 de 25

1

Stability is an important consideration in the formulation of emulsions. Which of the following represents an irreversible phenomenon in terms of re-dispersion of emulsion?

Selecciona una de las siguientes respuestas posibles:

Creaming
Coalescence of droplets
Flocculation
None of the above

Explicación

Pregunta 23 de 25

1

Given that the API is soluble in water, which of the following type of emulsion is desirable to formulate?

Selecciona una de las siguientes respuestas posibles:

O/W
W/O
None of the above

Explicación

Pregunta 24 de 25

1

	Creado por Jon dL hace más de 7 años

Test sobre Pharmaceutics I, creado por Jon dL el 07/03/2017.

Pharmaceutics I

Pregunta 1 de 25

By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the minimum number of phases present in a dispersed system?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 2 de 25

The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of the dispersed phase?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 3 de 25

Why might a dispersed phase containing drug be formulated in a dispersion medium in which it was insoluble?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 4 de 25

Given the equation for Stoke’s law of settling below, by how much you have to increase the viscosity to offset a particle size increase of a factor of two?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 5 de 25

Given a suspension with a fixed particle size distribution, what would be true if each powder particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of dispersion medium)?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 6 de 25

The primary mechanism of altering dispersion medium properties is modification of:

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 7 de 25

Which of the following characteristics is NOT desirable in the case of suspension dosage forms?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 8 de 25

An advantage of a shear thinning formulation includes:

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 9 de 25

Under what conditions would you compound a suspension using benzyl alcohol or propylene glycol for preemies?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 10 de 25

You are asked to compound a suspension of a drug normally dispensed as a solid dosage form. Why is it prudent to determine if a liquid dosage form is also commercially available?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 11 de 25

Select the choices that correctly fill the blanks in the following statement: the three minimum requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) ____ 2)____ 3)____.

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 12 de 25

Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically unstable?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 13 de 25

Patients should virtually never be instructed to store an emulsion dosage form:

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 14 de 25

The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 15 de 25

A magma is a:

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 16 de 25

In a colloidal dispersion the particle size is:

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 17 de 25

Which of following is FALSE in case of gel formulation exhibiting syneresis?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 18 de 25

What is a major function of glycerin in the carboxymethylcellulose based gel formulations?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 19 de 25

Which of following if true of aerosol used to provide an airborne mist?

Selecciona una de las siguientes respuestas posibles:

Explicación

Pregunta 20 de 25

A properly prepared pharmaceutical suspension should settle slowly and should readily re dispersed upon gentle shaking on the container

By the definitions from out notes for disperse systems, “Generally, a liquid preparation in which a
finely divided, insoluble or immiscible material is distributed throughout a vehicle”, what is the
minimum number of phases present in a dispersed system?

The distinction between the terms coarse, fine, colloidal dispersion is based upon what property of
the dispersed phase?

Why might a dispersed phase containing drug be formulated in a dispersion medium in which it
was insoluble?

Given the equation for Stoke’s law of settling below, by how much you have to increase the
viscosity to offset a particle size increase of a factor of two?

Given a suspension with a fixed particle size distribution, what would be true if each powder
particle displaced its own weight of dispersing phase (i.e. density of dispersed phase = density of
dispersion medium)?

Under what conditions would you compound a suspension using benzyl alcohol or propylene
glycol for preemies?

You are asked to compound a suspension of a drug normally dispensed as a solid dosage form.
Why is it prudent to determine if a liquid dosage form is also commercially available?

Select the choices that correctly fill the blanks in the following statement: the three minimum
requirements (i.e., 3 rules) needed for form a stabilized emulsion are 1) 2) 3).

Which of the following statements is NOT a valid criterion for suspecting an emulsion is physically
unstable?

The HLB system is primarily useful for matching a non-ionic surfactant system with the oil phase
in an emulsion. Given that: HLB Span 60 = 4.7, and HLB of Tween 60 = 14.9 estimated fraction of
Span 60 and Tween 60 needed to achieve an HLB of 12 is approximately (to the nearest %):

A properly prepared pharmaceutical suspension should settle slowly and should readily re
dispersed upon gentle shaking on the container