Inflamación

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Capítulo 3 del Robbins "Basic Pathology"
Lupita Farron
Flashcards by Lupita Farron, updated more than 1 year ago
Lupita Farron
Created by Lupita Farron about 7 years ago
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¿Qué es la inflamación? Is a response of vascularized tissues to infections and tissue damage that brings cells and molecules of host defense to the sites where they are eliminate the offending agents
Mediadores de la inflamación incluyen... Phagocytic leukocytes, antibodies, and complement proteins in the blood
2 tipos de inflamación... Aguda y Crónica
Características de la inflamación aguda Una vez resuelta, el tejido Sea reparado, si no --> CRÓNICA -Respuesta rápida, inicial -Desarrollo de minutos a horas -CORTA DURACIÓN (horas a pocos días) -Exudación de fluido y proteínas del plasma (EDEMA) -Migración de leucocitos, sobretodo neutrófilos
Características de la inflamación crónica Después de inflamación aguda o de novo -DURACIÓN + LARGA -Asociada a más destrucción de tejido -Presencia de linfocitos y macrófagos -Proliferación de vasos sanguíneos -Fibrosis
Inductores de inflamación Mediadores químicos producidos por célula hospedadora en respuesta a un estímulo dañino
Manifestaciones externas de inflamación -Heat (calor) -Redness (rubor) -Swelling (tumor) -Pain (dolor) -Loss of function (pérdida de funciones)
The inflammatory reaction becomes the cause of disease, and the damage it produces is its dominant feature Example: inflammatory reactions to infections are often accompanied by local tissue damage and its associated signs and symptoms there are many diseases in which the inflammatory reaction is misdirected, occurs against normally harmless environmental substances that evoke an immune response or is excessively prolonged
Silent killer inflammations Inflammatory reactions underlie common chronic diseases, such as rheumatoid arthritis, atherosclerosis, and lung fibrosis, as well as life-threatening hypersensitivity reactions to insect bites, drugs, and toxins
Inflammation is terminated when the offending agent is eliminated The reaction resolves because mediators are broken down and dissipated, and leukocytes have short life spans in tissues. In addition, anti inflammatory mechanisms are activated, serving to control the response and prevent it from causing excessive damage to the host. After inflammation has achieved its goal of eliminating the offending agents, it sets into motion the process of tissue repair. Repair consists of a series of events that heal damaged tissue. In this process, the injured tissue is replaced through regeneration of surviving cells and filling of residual defects with connective tissue (scarring)
Causas de inflamación... -Infecciones (bacterial, viral, fungal, parasitic) -Necrosis tisular (isquemia, trauma, heridas físicas o químicas) -Cuerpos extraños -Reacciones inmunes (hipersensibilidad lleva a enfermedades autoinmunes)
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