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| Question | Answer |
| What is the rationale for angina treatment? | 1. Provide symtpom relief 2. Reduce risk of MI and death |
| Which class of drugs is used for angina symptom relief and name one drug | Class:Short acting nitrates Drug: Glyceral trinitrate |
| Which route are short acting nitrates taken? | Sublingually, to provide rapid relief for angina symptoms |
| What is the MOA of nitrates? | producing vasodilation --> reduce venous return and preload to the heart, reducing myocardial oxygen requirement |
| What is the first line treatment for Angina? | Beta Blockers : eg: Metoprolol |
| What medication is used to treat Angina if Beta Blockers are contraindicated? | CCB - verapamil |
| Can beta blockers be stopped immediatley | No, abrupt withdrawl may lead to increased risk of MI and sudden death |
| Name a long acting nitrate and describe what they are used for | Transdermal glyceryl nitrate (patch), used to prevent chronic angina in patients wih more frequent symptoms |
| Advise on a practice point for Nitrates in hte treatment of Angina | 1. Tolerance occurs can can occur wth 24hr, so nitrate free intervals are required 10-12 hours per day |
| How long should a patient keep short acting oral tablet nitrates prior to disposal | Once open, glyceral nitrate sublingual tablets shelf life is 3 months, compared to oral spray 2 years. |
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