AQA biology 2.8 enzyme inhibition

Question	Answer
what is the type of enzyme called where it makes a temporary attachment to the active site?	reversible inhibitors
what are the two types of reversible inhibitor?	competitive and non-competitive
where to competitive inhibitors bind?	to the active site of the enzyme
where do non-competitive inhibitors bind?	to the enzyme at a position other than the active site
what is the inhibitors shape?	molecular shape similar to that of the substrate
what does this alllow them to do?	occupy the active site
what do they compete with?what for?	they compete with the substrate for the available active sites
what determines the effect this has on enzyme activity?	the difference between the concentration of the inhibitor and the concentration of the substrate
what happens if substrate concentrations are increased?	effect of the inhibitor is reduced
what is an example of competitive inhibition in a respiritory enzyme?	Malonic acid inhibits the enzyme because it has a very similar shap to succinic acid. Blocks succinic acid combining with enzymes active site
what happens when a non-competitive inhibitor binds to the enzyme?	the inhibitor alters the shape of the enzymes active site so substrate molecules can no longer fit so enzyme cant function
what effect does increasing the concentration of the substrate do?	no effect as the substrate and the inhibitor aren't competing for the same site

Resource summary

	Created by Charlotte Hewson over 9 years ago