Human Physiology - Lecture 1

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Biomolecules and Cell Structure
Amy M
Flashcards by Amy M, updated more than 1 year ago
Amy M
Created by Amy M about 9 years ago
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Question Answer
Carbohydrates Primary source of energy for cells (CH2O)n Monosaccharides Disaccharides Polysaccharides
Monosaccharides Glucose Fructose Galactose Ribose Deoxyribose
Lipids Non-polar molecules Can be Amphipathic Triglycerides Phospholipids Steroids
Triglycerides Backbone – Glycerol molecule Three chains of Fatty Acids
Phospholipids Amphipathic Head – Polar – Hydrophilic Tail – Non-polar – Hydrophobic Form biological membranes
Steriods Ring Compounds Cholesterol Some function as Hormones: Testosterone Estradiol Cortisol
Proteins Polymers of Amino Acids Primary, Secondary, Tertiary, Quaternary Can be Fibrous or Globular
Nucleotides Used in Transfer of Energy with cells Form Genetic Material Components 5-Carbon Sugar+Phosphate Group+Nitrogenous Base
Nucleic Acids Function in storage and expression of genetic information Polymers of Nucleotides DNA RNA
Plasma Membrane Separates cell from interstitial fluid Fluid Mosaic Model: contains free floating fluid phospholipids, cholesterol, mosaic proteins and carbohydrates.
Nucleus Membrane-bound structure that contains genetic information
Cytoplasm Everything inside cell except nucleus. Cytosol = intracellular fluid Organelles = carry out specific functions – can be Membranous or Nonmembranous
THE PLASMA MEMBRANE
Phospholipid Bilayer Hydrophilic heads facing aqueous Hydrophobic tails facing each other Basic structure of membrane Fluid part of membrane Barrier to large polar molecules
Cholesterol in the Plasma Membrane Found in lipid bilayer Prevents hydrophobic interactions Decreases fluidity/increases stability Decreases movement of water
Membrane Proteins Integral Proteins: Embedded within bilayer, some are Transmembrane – Channels and Carrier Proteins Peripheral Proteins: Bound loosely, Most on cytosolic surface Function with Cytoskeleton
Membrane Carbohydrates Bound to Lipid or Proteins Found on Extracellular Surface Glycocalyx – holds cells together Also functions in cell recognition
Nucleus Contains genetic material Surrounded by Double-layered Nuclear Envelope Two membranes Nuclear Pores allow movement between nucleus and cytoplasm Nucleolus – synthesis of rRNA
Cytosol Fluid that bathes Organelles Site of chemical reactions Storage sites: Inclusions, Secretory Vesicles
Endoplasmic Reticulum Rough ER – has ribosomes = Protein synthesis Smooth ER – Lipid synthesis and calcium storage
Golgi Apparatus Flattened sacs – Cisternae Processes and packages molecules
Lysosomes Contain enzymes Function to degrade debris, recycle old organelles Engulf debris by endocytosis
Peroxisomes Also degrade materials Produce Hydrogen Peroxide Catalase breaks down hydrogen peroxide into water and oxygen
Ribosomes Ribosomal RNA and protein Function in Protein Synthesis Large and Small subunits
Mitochondria Bound by two membranes. Outer Membrane separates mitochondria from cytosol. Inner Membrane divides mitochondria into Compartments a. Intermembrane Space b. Mitochondrial Matrix Inner Membrane houses Electron Transport Chain and is folded into Tubules called Cristae
Centrioles Short, cylindrical structures consisting of bundles of protein filaments Function during cell division – form mitotic spindles
Cytoskeleton Gives cell support and structure Functions in transport and movement Includes: microfilaments (smallest), microtubles (largest), & intermediate filaments.
Tight Junctions Seen in Epithelial Tissues Cells are fused via Integral Membrane Proteins called Occludins Impermeable Barrier
Desmosomes Found in areas subject to Mechanical Stress Filamentous Junction Includes a Plaque that is formed by Glycoproteins Cadherins – protein filaments that extend from Plaque and link cells together
Gap Junctions Seen in smooth and cardiac muscle Cells connected by membrane proteins called Connexins Connexins form Channels called Connexons that allow ions and small molecules to move between cells Makes cells Electrically-coupled
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