361883
Description
Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
about 11 years ago
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| Question | Answer |
| Location of the thymus | Just above the heart |
| Gross structure of thymus | 2 lobes |
| 2 Main Areas of Thymus | Cortex & medulla |
| Location of Positive Selection | Cortico-Medullary Junction |
| Positive Selection | Cortical Epithelial cells select T-Cell that can bind to them |
| Effect of cortex on T-cells | Lose B cell function and gain CD4 & 8 markers |
| T-cell specialisation | They lose either CD4/CD8 markers |
| Purpose of Negative Slection | Prevent autoimmune disorders |
| Negative Selection | T-cells with high affinity for cortico-medullary junction cells are destroyed |
| Thymus defects | Cause autoimmune disorders |
| Location of Spleen | Left of abdomen |
| White pulp of spleen | Lymphocytes/immune surveillance |
| Red pulp of Spleen | Destruction of aged erythrocytes |
| Detection of aged erythrocytes | Aged R.B.C's are inflexible and cannot pass through microcapillaric system |
| Debris and pathogens in spleen | Removed by microphages |
| Only Lymphatic Tissue | Lymphatic Nodules (NOT NODES) |
| Lymphatic Tissue | Not surrounded by capsule |
| Lymphatic Nodules- Mouth | Tonsils |
| Lymphatic Nodules- Intestines | Appendix |
| Lymphatic Nodules- Respiratory Tract | Mucosa associated lymphatic tissue |
| Cells contained by lymphatic nodules | B-cells |
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