48468
Description
Flashcards by Bhavi Mistry, updated more than 1 year ago
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Created by Bhavi Mistry
over 11 years ago
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| Question | Answer |
| Iproniazid | Irreversible non-selective MAO inhibitor |
| Moclobemide | Reversible MAO Inhibitor Depression and social anxiety |
| Phenelzine | Non-selective irreversible MAO inhibitor |
| Amitriptyline | TCA |
| Clomipramine | TCA |
| Desipramine | TCA |
| Desipramine | TCA |
| Fluoxetine | SSRI |
| Paroxetine | SSRI |
| Citalopram | SSRI |
| Reboxitine | NRI |
| Venflaxine | serotonin-norepinephrine reuptake inhibitor (SNRI) |
| Trazodine | serotonin antagonist and reuptake inhibitor (SARI) |
| Agomelatine | MT2 antagonist 5HT2 antagonist |
| Stress - depression progression | Leads to an increase in GLU transmission and cortisol, but decreases Dopamine/monoamine transmission Decrease in neurogenesis, increase in neural apoptosis Increase in depressive symptoms |
| MAOA Is | Degrade 5HT |
| MaOB Is | Degrade DA and NA |
| Side effects of MAO Is | Muscarinic (M1) Postural hypertension (A1) Sedation (H1) weight gain (5ht2) |
| Tricyclic antidepressants | Inhibits ma reuptake (5ht and na) Some alpha 2 adrenoceptor antagonism |
| Side effects of tricyclic antidepressants | Histamine Muscarininc Alpha 1 5HT2 Cardiotoxicity (binding site on heart) |
| NARIs + SSRIs + SNRIs (Selective reuptake inhibitors) | prevent 5HT and NA reputake Lack/reduced TCA side effects |
| NARIs + SSRIs + SNRIs (Selective reuptake inhibitors) | prevent 5HT and NA reputake Lack/reduced TCA side effects |
| 5HT3 side effects of selective re-uptake inhibitors | Nausea Anorexia |
| 5HT2 side effects of selective re-uptake inhibitors | Insomnia Sexual dysfunction 5HT syndrome (suicide - adolescents only) |
| NA related side effects of selective re-uptake inhibitors | Insomnia Constipation Sweating Tachycardia Anxiety, irritability, aggression |
| Mirtazipine | alpha 2 antagonist 5HT 2 + 3 antagonist Does not antagonise 5HT1 (beneficial effects still present - TCA usually block 5HT1 --> negative side effects) |
| Atypical drugs | SNRI (Serotonin - NA RI) SSRI + 5HT2 antagonist SNRI + 5HT2 antagonist Alpha 2 and 5HT antagonist |
| Lithium | Replaces Sodium decreasing excitability Alters signalling via 2nd messengers Gene expression first line therapy in bipolar disorders Mood stabiliser |
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