Flashcards
Antidepressants
Cards in this deck (28)
- 1IproniazidIrreversible non-selective MAO inhibitor
- 2AgomelatineMT2 antagonist
5HT2 antagonist - 3Trazodineserotonin antagonist and reuptake inhibitor (SARI)
- 4Venflaxineserotonin-norepinephrine reuptake inhibitor (SNRI)
- 5ReboxitineNRI
- 6CitalopramSSRI
- 7ParoxetineSSRI
- 8FluoxetineSSRI
- 9DesipramineTCA
- 10DesipramineTCA
- 11ClomipramineTCA
- 12AmitriptylineTCA
- 13PhenelzineNon-selective irreversible MAO inhibitor
- 14MoclobemideReversible MAO Inhibitor
Depression and social anxiety - 15Stress - depression progressionLeads to an increase in GLU transmission and cortisol, but decreases Dopamine/monoamine transmission
Decrease in neurogenesis, increase in neural apoptosis
Increase in depressive symptoms - 16MAOA IsDegrade 5HT
- 17MaOB IsDegrade DA and NA
- 18Side effects of MAO IsMuscarinic (M1)
Postural hypertension (A1)
Sedation (H1)
weight gain (5ht2) - 19Tricyclic antidepressantsInhibits ma reuptake (5ht and na)
Some alpha 2 adrenoceptor antagonism - 20Side effects of tricyclic antidepressantsHistamine
Muscarininc
Alpha 1
5HT2
Cardiotoxicity (binding site on heart) - 21NARIs + SSRIs + SNRIs (Selective reuptake inhibitors)prevent 5HT and NA reputake
Lack/reduced TCA side effects - 22NARIs + SSRIs + SNRIs (Selective reuptake inhibitors)prevent 5HT and NA reputake
Lack/reduced TCA side effects - 235HT3 side effects of selective re-uptake inhibitorsNausea
Anorexia - 245HT2 side effects of selective re-uptake inhibitorsInsomnia
Sexual dysfunction
5HT syndrome (suicide - adolescents only) - 25NA related side effects of selective re-uptake inhibitorsInsomnia
Constipation
Sweating
Tachycardia
Anxiety, irritability, aggression - 26Mirtazipinealpha 2 antagonist
5HT 2 + 3 antagonist
Does not antagonise 5HT1 (beneficial effects still present - TCA usually block 5HT1 --> negative side effects) - 27Atypical drugsSNRI (Serotonin - NA RI)
SSRI + 5HT2 antagonist
SNRI + 5HT2 antagonist
Alpha 2 and 5HT antagonist - 28LithiumReplaces Sodium decreasing excitability
Alters signalling via 2nd messengers
Gene expression
first line therapy in bipolar disorders
Mood stabiliser
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- under grad Neuro-pharmacology Flashcards on Antidepressants, created by Bhavi Mistry on 17/04/2013.
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- Bhavi Mistry
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