Enzyme Inhibition

Question	Answer
Name two types of enzyme inhibitors	1) Competitive inhibitors 2) Non-Competitive Inhibitors
Where does a competitive inhibitor bind to?	The enzymes active site
How do competitive enzymes decrease the rate of a reaction?	They bind to the active site of an enzyme, blocking the substrate from binding to it and forming an enzyme-substrate complex so the rate of the reaction is decreased.
What feature of competitive inhibitors allows them to bind the the active site of the enzyme as if they were the substrate?	They have a similar shape to the substrate
Where do non-competitive inhibitors bind to?	Non-competitive inhibitors bind to the allosteric site
Once a non-competitive inhibitor binds to an enzyme, what happens to the rate of reaction and why?	The rate of reaction decreases dramatically when a non-competitive inhibitor is introduced. This is becasue when a non-competitive inhibitor binds to the allosteric site, it causes the active site to change shape. This means the substrate no longer fits and no more enzyme-substrate complexes are formed.
In a non-competitive reaction mixture, if you increase the substrate concentration, what happens?	Nothing happens as substrate concentration doesn't effect non-competitive inhibition

Resource summary

	Created by Bee Brittain over 8 years ago