6049462
Description
Flashcards by Emma Allde, updated more than 1 year ago
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Created by Emma Allde
over 8 years ago
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| Question | Answer |
| Duchenne and Becker Muscular Dystrophy is caused by a mutation in what protein | dystrophin |
| Duchenne and Becker Muscular Dystrophy affects which cytoskeletal protein | actin |
| What is the function of dystrophin | vital part of a protein complex that connects the cytoskeleton of a muscle fibre to the surrounding extracellular matrix through the cell membrane |
| What are the symptom of Duchenne and Becker Muscular Dystrophy | |
| Usher's syndrome affects which cytoskeletal protein | actin |
| What are the main symptoms of Usher's syndrome | Hereditary deafness and blindness |
| Epidermolysis bullosa simplex affects which cytoskeletal protein | intermediate filaments |
| What causes epidermolysis bullosa simplex | mutations in keratin genes results in failure to form proper keratin filaments in epidermis |
| What are the main symptoms of epidermolysis bullosa simplex | • skin highly sensitive to mechanical energy • blistering in adults and sloughing of epidermis in newborns |
| Muscular dystrophy affects which cytoskeletal protein | intermediate filaments |
| What is the cause of muscular dystrophy | plectin mutations |
| What is the role of plectin | a protein that binds to intermediary filaments these molecules link to IFs and to actin filaments and microtubules to form the net-like structure |
| Amyotrophic lateral sclerosis (ALS) or Motor Neuron disease is sometimes caused by mutations in which cytoskeletal protein | intermediary filaments |
| Some hereditary forms of Amyotrophic lateral sclerosis (ALS) or Motor Neuron disease are caused by what | neurofilamin genes |
| What is the main symptom of Amyotrophic lateral sclerosis (ALS) or Motor Neuron disease | Neural degeneration |
| Alzheimer's disease alongside amyloid plaques, AD brains display neurofibrillary tangles comprising which cytoskeletal protein | microtubules |
| Specifically, which MAP is implicated in Alzheimer's disease | Tau |
| What is tau | Hyperphosphorylated in tangles that cannot bind microtubules |
| Which cytoskeletal protein is implicated in Hereditary Spastic Paraplegia | microtubules |
| Specifically, which MT is implicated in Hereditary Spastic Paraplegia | spastin |
| What is spastin | microtubule severing protein |
| Listeria bacteria hijack which cytoskeletal protein | actin |
| What does listeria to cytoskeletal protein | • hijack actin of cytoskeleton • engulfed by host cell • escapes from phagocytic vesicle • F-actin is polymerised at the back of it, providing motility • actin 'comet' drives it into the neighbouring cell" |
| What is Listeriosis | infections of the central nervous system (meningitis, meningoencephalitis, brain abscess, cerebritis) and bactereia in those who are immunocompromised from eating contaminated foods |
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